The Associated Research Between Tcm Syndrome Difference Of White Lesion Of Vulva And Polymorphism Of HLA-A\-B\DRB1Genes

OBJECTIVE To investigate HLA-A\B\DRB1level in TCM syndrome difference of white lesion of vulvar. We try to probe into the influence of genetic susceptibility factors on the disease of white lesion of vulva.And it also supply the reference for the next study.METHODS All150patients who suffered from white lesion of vulva were divided into four groups.38cases were chose to be squamous cell hyperplasia (SH), and36patients were chose to be lichen sclerosus (LS) by the TCM syndrome of Liver meridian hot and humid. Other36patients were chose to be squamous cell hyperplasia (SH), and40patients were chose to be lichen sclerosus (LS) by the TCM syndrome of Yin-deficiency of the Liver and Kidney. These groups of HLA-A,-B,-DRB1genes polymorphism were detected and analysed using PCR/SSP.RESULTS HLA-B*15genes in all patients were obviously higher than normal group. And HLA-DRB1*12genes in all A,B,D groups were obviously higher than normal group. On the contrary, HLA-B*40genes in A,C,D groups were obviously lower than normal group. HLA-B*40,HLA-DRB1*12genes in patients groups have statistical significance (P<0.001).The polymorphism of HLA-A\B\DRB1genes has relation with TCM syndrome of white lesion of vulva. HLA-A*02genes in C groups were obviously lower than normal group. And HLA-DRB1*12genes in patients groups have statistical significance (P<0.001)CONCLUSIONS People with HLA-B*15genes are likely to suffer from the white lesion of vulva. And people with HLA-DRB1*12genes are likely to suffer from the squamous cell hyperplasia and the lichen sclerosus by the TCM syndrome of Liver meridian hot and humid, also lichen sclerosus by the TCM syndrome of Yin-deficiency of the Liver and Kidney. On the contrary, people with HLA-B*40genes are unlikely to catch this disease. Especially in the squamous cell hyperplasia and the lichen sclerosus groups by the TCM syndrome of Yin-deficiency of the Liver and Kidney, and in the group of squamous cell hyperplasia by the TCM syndrome of Liver meridian hot and humid.In addition to the above results,we also find HLA-A*02genes are the protective genes in the group of squamous cell hyperplasia by the TCM syndrome of Yin-deficiency of the Liver and Kidney. The significant difference of HLA-B*40, HLA-DRB1*12and HLA-A*02genes in each group points out the materical evidence to TCM syndrome and the importance of individual discrepancy.And it is significant to diagnose, treat and forecase the disease.It is also important for the TCM syndrome.