| Processing drugs is a traditional pharmacy technology based on the traditional theories, the requirements of treatment, the quality nature of drugs and the different demands of dispensing. Traditional Chinese medicine (TCM) will strengthen its effect and degrade its toxicity by processing. There are many processing drugs which change their effects by processing are recorded in various ancient literatures such as rough Shengdi and processed Shengdi, rough Xijian and processed. However there are some difference between the traditional and contemporary processing methods and aims. In order to solve these problems, a lot of literature research and experiments are needed. Xijian herb is a kind of annual herb recorded first in the XIN XIU BEN CAO. According to traditional theories rough Xijian mainly aims at clearing liver-heat and toxic material and is used to cure furuncle, rubella, eczema and so on. When Xijian is processed with alcohol, it has the effects of eliminating rheumatism, strengthening bones and muscles, and making up liver and kidney . Then it is used to cure palsy, rheumatic and so on. Xijian pill has been recorded in the Chinese Pharmacopoeia from 1963. The pill preparative method in Pharmacopoeia differs in the traditional one. So this study aims at probing the possibility of solving the problems of processing drugs with literature research and contemporary experiments. Our work began with literature review of Xijian herb and Xijian pill. Then we compared the effects and ingredients of rough Xijian and processed Xijian. Furthermore we optimized the prescription and discussed the mechanism. 1. Literature researsh Motive Because of the difference between traditional and contemporary effects, we reviewed the plant origin, applying part, processing history, preparation and application of Xijian in order to collect the background information of Xijian pill. Result Contemporary applying part and the processing method of Xijian are different from traditional ones. When it comes to the effects and prescription, there still are some differences between traditional and contemporary Xijian. At the some time, the effects of rough Xijian and processed Xijian are also different. 2 Processing HERBA SIEGESBECKIAE of drug action and chemical composition to contrast and study in circa . 2.1 Motive XIJIAN pill rough product and processed product for antiinflammatory anti-rheumatism and chemical composition to contrast and study to reveal processed product HERBA SIEGESBECKIAE chang in drug action and ingredient 2.2 Test methods and Result processed product HERBA SIEGESBECKIAE have apparently depressant effec to Acute inflammation chronic inflammation and immunity inflammation.it better thanrough product. acute toxicity test presentation of resultsrough product and processed product is innocuity ;thin layer chromatography convict rough product andprocessed product have much difference. 2.3 Conclusion HERBA SIEGESBECKIAE rough product and processed product have much difference in drug action and chemicial composition. 3 To make use of direct design of experiment method grading-up XIJIAN pill prescription. 3.1 Motive With drug action and chemical index to find best prescription and suitable dosage. 3.2 Method To use direct design of experiment method .tow factors are rough pachy stem and wine parboil tender stem.to set up seven levels.Then applying RDZ software compute.we can get a plan that need seven time experiments. We Select IL-1βand IL-6 synovial fluid for chemicial index that judge immunity inflammation and pathogenetic condition severity.the same time we shoose nonanol that is composition of HERBA SIEGESBECKIAE. Nonanol contents is pharmacodynamics foundational index to get grading-up prescription 3.3 Result The best prescription: rough pachy stem 0g ;wine parboil tender stem 30g. 4 To probe grading-up XIJIAN pill prescription treat ostarthritis of drug efficacy study and mechanism of action. 4.1 Motive With pharmacodynamics immunology histomorphology to sure the depressant effect to infl.and find t...
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