Association Study Of PPARGC1 And Coacivator Gene Polymorphism With Aerobic Performance

The aim of this work was to examine the association between the polymorphisms in PPARGC1,NRF1,NRF2 and TFAM gene and aerobic performance.PartⅠ:Association study of PPARGC1 and coactivator genes with elite aerobic performanceSubjects:123 endurance athletes and 206 controlsMethods:The case-control studies were to analyze the gene polymorphisms characteristic between endurance athletes and controls.These polymorphisms were located in PPARGC1(Thr394Thr,Gly482Ser,A2962G), NRF1(rs2302970,rs6949152,rs10500120),NRF2(rs12594956,rs80311031, rs7181866) and TFAM(rs1937,rs2306604,rs1049432) gene.Results:A2962G polymorphism was associated with elite aerobic performance with sexual difference.The frequency of G allele was significantly higher in elite male endurance athletes than male controls, while the A allele frequency was significantly higher in elite female athletes than female controls.Meantime,the PPARGC1 gene ACA haplotype was only appeared in elite male athletes,and the ACG haplotype frequency was significantly higher in elite male athletes than male controls.PartⅡ:Association study of PPARGC1 and coactivator genes with aerobic phenotypesSubjects:102 healthy,biologically unrelated young males from Northern China(of Han origin) Methods:The cross-sectional association studies and association studies with training response phenotypes were used to explore the genetic markers for aerobic phenotypes,such as VO2max,running economy,left cardiac structure and function at baseline and in response to training.Results:1) A2962G polymorphism was associated with VO2max at baseline, as carriers of the G allele(AG+GG genotypes) had higher levels of VO2max than the AA group.2) The VO2 at RE was associated with rs80311031, rs2302970 and NRF2 haplotype at baseline,whose carried CC,CT genotype or ATG haplotype had higher running economy capacity,respectively. However,the training response of VO2 at RE was associated with rs6949152, rs2302970 and NRF2 haplotype,and the group with AG,CT genotype or ATG haplotype were higher.Conclusion:1) A2962G and PPARGC1 gene haplotype might be the genetic markers in predicting male elite athlete.2) A2962G,rs2402970,rs6949152 and NRF2 gene haplotype might be the genetic markers in predicting the aerobic phenotypes.