Preparation And Evaluation Functional Of Acanthopanax Senticosus Water-soluble Bioactive Molecules

Acanthopanax is the roots of Acanthopanax senticosus(Rupr.et Maxim.),in the northeast,north of China regions as the main distribution with a very rich resources.Stem,leaf and fruit from Acanthopanax can be used as medicine;Acanthopanax has a anti-radiation role,adjust the white blood cells;Treatment of diseases such as diabetes,lung,hypotension and hyperlipidemia.Acanthopanax preparations can sleep improvement,A Fuzzy memory and prevent arrhythmia,anti-fatigue effect.There are many kinds of nucleoside compounds from Acanthopanax roots,such as acanthopanax quercetin glycosides(carrot),A acanthopanax glycosides B(the beta dextrose glucoside of syringa)was also called the lilacs glycosides,coumaric glycosides:acanthopanax glycosides B1,acanthopanax glycosides(x-gal)C,acanthopanax nucleoside D,and E(2 different configurations of glucoside),acanthopanax glycosides and acanthopanax nucleoside F G,etc.Acanthopanax glycosides D and E(lignin glycosides)as the phenolic glycosides,acanthopanax lilacs glycosides in accounted for about 30%of total glycosides,acanthopanax fruit contains mucopolysaccharide.These polysaccharides include:arabinose,glucose,galactose,rhamnose,xylose,etc.Phenolic glycosides compounds not only have anti-fatigue and anti-cancer effect,but also enhance DNA synthesis.However,acanthopanax active ingredient had a lower water-solubility,easy to anaphylactic reaction,hard to used for clinical;there were relatively unknown purpose of effective ingredient Acanthopanax labels in the market,low bioavailability.As a result,we need to occupied the international market that get a kind of mature water soluble preparation methods to promote our country acanthopanax enterprises rapidly,to achieve higher results.This article conducts the research Based on the extract of acanthopanax,preparation and biological function,the use of precision analysis and feasibility studies of acanthopanax substrates on System,a full of acanthopanax use.such as:(1)preparation acanthopanax extract;Macroporous adsorption resin commonly used as a material can be the role of van der Waals force and hydrogen bond to selectively adsorption of aqueous composition.And the strength of the adsorption were determines by macroporous adsorption resin.At the same time,macroporous adsorption resins with high adsorption capacity,easy to parse,low cost and easy regeneration,etc,there is the best choice to preparation macroporous resin for acanthopanax extract.(2)preparation water-soluble acanthopanaxt freeze-dried buccal table:after enrichment of acanthopanax extract,the water dissolves to 40 ? precool 4 h;buccal tablet becomes flat surface and a certain luster.After lyophilization of water-soluble acanthopanax buccal tablet becomes shallow be khaki,smooth surface,the edge of the near lozenges strategy polished;there are different sizes of crack tank or crack in the buccal tablet.Water-soluble acanthopanax freeze-dried buccal tablet with uniform morphology,surface level off,has the characteristics of porous structure and good solubility in water.(3)Mix up the stem,foliage and seed from acanthopanax water solution,homogenizer for homogeneous 3 times and monitoring the particle size at the same time;within in the lyophilizer after lyophilization,the drying temperature was 40 ?,reaches 1 pa under the condition of vacuum freeze-drying;Collected powder is water-soluble acanthopanax stem producing body.(4)We test the Acanthopanax powder by SEM,laser particle size instrument and HPLC instruments;the water soluble acanthopanax powder were characterized and biological detection.Different tests can be seen clearly under the condition of acanthopanax Ghana m producing micro forms were scattered in the nano small bump;by means of preparation of water-soluble nanoparticles surface ratio increases significantly,the higher solubility in water.(5)The main process of preparation of acanthopanax residue alkaline fiber and lignin.According to a certain amount of acanthopanax root residue in the high-pressure kettle,a certain concentration of lye temperature to react,arrived at the scheduled time,Refrigerant temperature mixture after unloading removed in centrifugal,collect the black liquor and join to the hydrochloric acid,adjust pH value to 3,centrifugal separation for coarse alkali lignin,and water washing to neutral,get 40 ? vacuum drying lignin filter cake,get brown powder in the alkaline lignin.