The Primary Study On Preparation And Quality Standard Of Likening Intestinal Pellets

Intestinal tract infectious diseases break out widely and have many complications. It not only does great harm to people's health and life, but also affect people's production and work.Currently the dosage forms of the treating drug are ordinary oral tablet, suppository, clyster and so on.However, these dosage forms have shortages, such as used inconvenience, the efficacy is not ideal, relapse rate is high and number of adverse reactions is more.Likening intestinal pellets is a modern Chinese medicine preparation which has antiseptic and antiviral curative effects, with no release in the stomach and positioning release in intestine.So that the drug can prolong and improve pharmacodynamic action due to high dense in intestine.In the basis of preliminary studies, this study includes shaping technology, coating technology and primary quality standards study for Likening intestinal pellet.This study prepared pellet cores with extrusion-spheronization method, after the prescription factor and the technology factor inspected, we determined Likening intestinal pellets the preparation technology, by which we obtained particle size 10-18 mesh pellets receiving rate above 75%, the result is quite ideal.The method of revolving pot coating contains pill core by intestinal materials. The single factor inspection has established the coating technology. Acrylic acid resin â…¡, â…¢ was the main thin film coating material, the coating pellet rate of finished products was high, finished produce can achieve at the intestines department release request by dissolve determination in vitro. At the same time the syringpicroside was qualitative investigation by the thin layer chromatography and quantitative investigation by HPLC. Thus the quality standard of Likening intestinal pellets was set up.