Studies On Biologically Active Diorganotin Complexes Containing Silicon Of Schiff Base Derived From Amino-acids

Recently diorganotin(â…£) complexes have received increased interest owing totheir structures and obvious anti-tumour activities. Lots of research works showed thatdialkyltin complexes have obvious anti-tumour activities, in particular the organotinesters of N-arylidene-amino acids have been observed to exhibit a great anti-tumouractivity against human tumour cell lines. In drug molecule whose certain C atom wassubstituted by a silicon atom was called silicon drug, the effect of the drug will bereserved and the toxicity be reduced. In order to study systematically the relationbetween structures and activities, sixteen new containing silicon diorganotincomplexes of salicylidene-amino acids by the reaction of diorganotin halide andSchiff base of amino acid in 1:1 stoichiometry in the reaction of triethylamine weresynthesized. Their structure were characterized by elemental analysis, IR, ¹H NMR,¹³C NMR, MS and X-ray diffraction. R¹=Me₃SiCH₂, EtMe₂SiCH₂ R²=Me₃SiCH₂, EtMe₂SiCH₂, Ph, Bu, Cy R³=H, CH₃, CH₃SCH₂CH₂, PhCH₂, CyCH₂The results indicated that the Sn atom in diorganotin Schiff base complexes wasfive-coordinated in trigonal bipyramidal geometries thanks to the existence ofintermolecular ligands of Sn←N.The preliminary bioassay tests results indicated that some of the diorganotincomplexes of salicylidene-amino acid have a good antiturnour activity in vitro againstA549 tumour cells.