Extract And Concentrate Technological Process And Quality Standard Research Of Jixing Yanyan Buccal Tablet

With the function of heat-clearing and detoxicating,dissipating phlegm and relieving sore-throat,promoting the production of body fluid and eliminating stagnation,the prescription of Jixing Yanyan buccal tablet comes from a laryngology clinical expert's experiment.Its effect is reliable and clear.We will apply modern extracting method and advanced compound preparation artwork to make it into buccal tablet for using efficiently.The prescription of Jixing Yanyan buccal tablet was composed by Flos Lonicerae Japonicae,Radix Platycodonis,Rhizoma Belamcandae,Radix et Rhizoma Sophorae Tonkinensis,etc.Based on the investigation of literature and the pre-experiment,we adopt ethanol recirculation to extract the medicines.We made component palmatine and tectoridin as the index,applied orthogonal experiment in the best artwork research of complex prescription extracting.According to the results of orthogonal experiment and industrial actuality, the best extrace artwork was as follows:Flos Lonicerae Japonicae replaced by extractive which could bought in market,Radix Platycodonis etc extracted by 60%EtOH 3 times,each time 1 hour.Under this condition,the reservation rate of component palmatine and tectoridin contained in extract solution can be 90%.Then,we studied the stability of extract solution by put them into 65℃waterbath 5 hours,and then investigated the quantity of component palmatine and tectoridin.The results of stability study shows that,the index components were steady.On quality standard study,we founded HPLC quantity determination method of caffeotannic acid contained in Flos Lonicerae Japonicae,and TLC identified methods for others.We founded TLC identified methods of Radix Platycodonis, Rhizoma Belamcandae,Radix et Rhizoma Sophorae Tonkinensis,etc,and HPLC quantity assay method of caffeotannic acid:used Octadecylsilane chemically bonded silica as fixed phase,acetonitrile-0.4%H₃PO₄ solution(13:87)as mobile phase,the flow rate is 1.0ml/min,column temperature is 30℃.The key to success in dosage improvement is based on technological processes and quality standard.The atricle proves the Ji-xing-yan-yan buccal tablet is well done.