Alleviation Of Piglets`early-weaned Stress With A Traditional Chinese Medicinal Compound Zhilishen

Early-weaned piglets suffer severe nutritional stress bue to poor feed intakeand poor ability of digestion and absorption in the first several days post weaningNutritional triss is the major component that causes early-weaned stress (EWS) in pigletand it is also the primary reason leading to the becreased performance of piglet afterweaning. This study was designed to alleviate piglet's EWS with a traditionald chinesemedichal compound Zhilishen which had functions of invigoration stomach,spleen andkidney and suppressing the growth of pathogens, etc.In a clilical experiment, crossbred piglets were randoml assigned into the treatmentsroup (59 piglets from 6 litters) or the control group (66 piglets from 7 litters). Zhilishenwas added into the dietary at the dose of l .5% of feed weight from 3 days before weaning to2 weeks post weaning in treatment group. All piglets with access to creep feed from 7 daysof age were weaned at 28 days of age. Two piglets from each litter (all piglets chosen hadsimilar body weight at weaning were repeatedly blood sampled at weaning (day 0).1-wkpost weaning (day 7) and 2-wk post weaning (day l4) for measuring some phyiology andbiochemistry indices including total white blood cells (WBC), lymphocytes (W-SCR) andneutrophils (W-LCR), ratio of neutrophil to lymphocyte (N/L),total protein (TP), albumin(ALB), globulin (GLOB), ratio of albumin to globulin (A/G),blood urea nitrogen (BUN),cholesterin (CH) creatine kinase (CK), aspartate transaminase (AST). Zn²⁺,cortisol. Theperformance of piglets within 2 weeks post weaning were recordedThe performance of piglets within 2 weeks post weaning were: (1)The incidence,frequency and scores of diarrhea in treatment group and in cotrol group were 37.3% and69.7% (p＜0．05),6.5% and 9.6% (P<0.05),7.25 and 11 .03,respectively.(2)average daily gain(ADG) Of the treatment group and the control group in the 1-st week the 2-nd week and theThesis of master's degreeds two weets poSt wi m eq nd 34g pe.0s). l70g nd l39g pe.0s). l20gand 86g oo.0l)wt. avmp bo ds (ADFI wer l57g andlasg (P<0.05), 288g nd 2l4g oo.0s). 2ng nd l70g oo.05-- at offedto gajn wer 2.28 aDd 3.68. l .69 and l .54. l .86 and l .wiThase rech betha the coul -- allfor the wi ds Of EWs an the --ofpiglet.be ed orbo mf(l)In bo po, wi wh the ds bo(on day 0), ds Ofsennn TP and GLO were lower on day 7 op.05) --serum us bo anu Mi at ed on 7 pe.oo) nd bo haedd tO recowr tO the ds leVe ou day l4'lh twof grOUP, ds c to theinhal lev4 cbo Of m TP ALB. GLO ail bo tw (for Thand GLO, po.0l and for ALB. P<0.05pewi on day 7 wforas AlG haObo on day 7 nd bo ds bo to m exop that sennn ALBcOncentIatirm M to for on day l4 to a leVe vny s-- foWer to<0.01)than the ds ha cwt with the COnwt serurn Th -- m high onday 7 (P<0.0l) and an l4 (P>0.0s) the serum ALB ds m higher on day7 pe.05) nd tw l4 pe.0l) in be po.(2w bo sbo on day 7ana excecod owr the ds bo on l4 in the po bo it boobvious on 7 op.0s) nd w ed bo the ds bo on l4 in for po.There wer no pe - in W-SCR all WMR th bo - gh weanjnin thebo pe. wSCR bo co day 7 arId ed to the ds bo ou l4but W-LCR bed s-- on day 7 oo.05) and wn still in bo leve on tw l4(P<0.05) in for po' he N& ds in bo pos bo on tw 7 nd ed torecover ou day l4.(3)lh bo srw rm are ds ds to bo on day7 and to are on day l4he the Won m wi.bo CHbo Of --'s -c-- bo COnW in both grOUPS -- the -- but itwas vere sied bo oo'0lpe on day 7 all day l4 than the ed leve inced has tw -- of CH on day l4 we fow oo.05) bo the dslevat in the mp. (5) Serum asT activity bo slighfy on day 7 (P>0.0s) andboH on day l4 to a bo that was bo oo'0s) bo tbc bo an tw 7 in aregrop, Ih wtul grmp, m AST activity bo vny s-- (P<0'0l) on day 7and thelined an day l4 to a levof that was tw fow oo'05) than the levd co day7.(6)Serum CK activity had no rnarbo tw within 2 wde POst weaning in trecogrOUP. In COntrD grOop, serum CK ed bo on day 7 and od...