Research And Development On The Anti-cancer Active Part Of Euphorbia Fischeriana Steud

This research is "Research and Development on new drug from anti-cancer active part of E.f financially supported by the new drug fund of the National Science Council.We studied the new drug's technology of preparation, quality and pharmacodynamics, according to demanding of topic designing and judgement measures on new drug of the traditional Chinese medicine. We mainly finished research data clinical anterior part.hi this research, for the first time, supercritical fluid extraction (SFE) was applied to the extraction of terpenoid component, special of diterpenoid lactone component. The best extraction technology was decided by orthogonal test. The extracts were prepared into soft gelatin capsule. The dose form, on the one hand, assured of organism utilization degree of the active part, on the other hand, stimulation odor of extracts was covered.Establishing the quality standard of preparation by IJV. TLCS. HPLC. The accuracy, repeatability, stability and recovery of determining method were all accord with the relevant regulations in the inspection of methodology.By means of phamiacodynamic research, we studied the E.f soft gelatin capsule's anti-tumor functions in vivo and in vitro. The test results verified that the E.f has different level inhibition to S180. H22 Lewis. Anti-tumor rate coincided with the relevant regulations.Six marker compounds were isolated from the active part of E.f by chromatographic methods and identified. We also preliminary' studied and discussed anti-cancer principle of E.f.