Study On Chemical Components And Quality Standard Of Radix Astragali In Xinjikang Injection

Xinjikang injection is an effective preparation to cure viral myocarditis(VCM).It consists of ingredients of Radix Salvia and Radix Astragali.The total saponin and total flavonind are active compounds in Radix Astragali. So the AstragalosideIV(AGSIV) should not be the only index to assess its quality and satisfy the demand for fingerprint chromatography of TCM injection .By column chromatography with silica-gel four compounds were isolated from Radix Astragali .That is AGSIV,onion, 9,10-dimethoxy-pterocarpan-3-O-β -D-glucopyranoside, 2' -hydroxy-3 ' ,4' -dimethoxy-isoflavan-7-O- β -D-glucopyranoside, Which can be used as the index to set up fingerprint chromatography of xinjikang injection.A colorimetric method was developed for the determination of total saponin and total flavonind. AGSIV and 2' -hydroxy-3' ,4' -dimethoxy-isoflavan-7- O- β-D-glucopyranoside were determined by HPLC. This experiment has set up a fingerprint chromatography of medium and xinjikang injection in Radix Astragali .The similatity was calculated with coefficient of correlation and cosine value of vectorial angel by Excel 2000 and the result is over 0.99 .It showes that the method can be used to control its quality effectively.With the TCM fingerprint chromatography and quantitative analysis of index constituents,the result of this study is showing that the method can reflect all the characteristic of TCM and is better than quantitative analysis of single index in Western medicine,.So it gives information for the quality assessment on xinjikang injection...