Preparation And Evaluation Of Zhigantuo Capsule

Systematical research of the compound prescription of TCM has been performed in this study. Preparation create technology study, preparation quality standard study, preparation stable quality study, preparation pharmacodynamics study and safety study of preparation are included in research content. In preparation, materials active composition is regarded as target, the orthogonal test is adopted, the factor influencing extracting is researched, The Salvia miltiorrhiza, Zexie under 90% alcohol reflux extract condition is determined twice, once 1 hour; The Yujin, Yinchen are crushed to be crude power, the steam is used to distillation extract volatilization oil four hours; The medicine dregs under 90% alcohol reflux extract condition and the medicine dregs extracted volatilization oil and baishao ,huzhang ,heshouwu and water boiled twice, first time 2hours are used, the second time 1.5 hours are used, the boiled water will be concentrated, the boiled water will emerge sediment when alcohol added to be 60%. β—cyclodextrion seal package is adopted, Under packed condition the material is grinded 2hours, dried under low temperature condition. The Paeonia Lactitlora, Polygonum rnultiflorum, Polygonum cuspidatum,Salvia miltiorrhiza contained in pharmaccutical manufacturing are identified by TLC. The content of baicalin contained in pharmaccutical manufacturing is determined by HPLC. The pharmaceutical manufacturing's toxicology and pharmacodynamics are investigated elementary, the result demonstrates that zhigantuo capsule has good anti-inflammation obviously and enchance immunization action, and decreases the content of CT and TG contained in rat's blood and high-fat model, result shows it safety and non-poisonous.