Bcl-2,Bax And Survivin Expression In Han And Uigur Women With And Without Endometriosis In Xinjiang

Objectives: Endometriosis is a kind of common diseases among childbearing age women,however it seems to be difficult to be overcome up to now.In the recent years, incidence of the endometriosis sends up rising trend. The etiological mechenism for the endometriosis could be compilicated,and it may be still not very clear at present,so also have not ideal therapeutic effect. Therefore we evaluate and compare Bcl-2, Bax, survivin gene experession in Han and Uigur women with and without endometriosis to explore possibility for the mechanism of the endometriosis. Methods: Bcl-2 and Bax expressions were assessed with use of imrnunohistochemical techniques. In situ hybridization techniques was used to examine the survivin expression,and were examined in the eutopic and ectopic endometrium of patients with endometriosis and eutopic endometrium of without endometriosis. Uigurs (15 controls and 22patients) and Hans (15 controls and 22patients). Apoptotic ceils were detected with use of the dUTP nick-end labeling (TUNEL) assay in 15 normal eutopic endometrium and 10 cases; Results: Bcl-2, Bax and survivin immuneoreac-tivity were found predominately in the glandular epithelial cells, Bcl-2 and survivin expression in eutopic and ectopic endometrium was significantly increased compared with the healthy controls, and Bax expression in eutopic and ectopic endometrium was significantly decreased compared with the healthy controls (p<0.05). An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from healthy controls. Bax expression was increased both proliferative and secretory endometrium in healthy controls, there was no significant difference in the...