| Background and ObjectivesEndometrial carcinoma (EC) has become one of three most common malignant tumors in feminine procreation organs/system and estrogen-dependent cancer. Obesity, hypertension, diabetes, nulliparity, menopause postponement etc are the high risk factors associated with endometrial cancer, but the pathogenenesis is not fully known so far. In recent years, the incidence of endometrial cancer increases quickly and holds approximately 7 percent of all kinds of malignant tumors in Chinese female, 20 to 30 percent of feminine reproductive tract malignant tumors. Most cases of EC are diagnosed in transitional years of menopausal and postmenopausal middle-aged women above the age of 50.Lymph metastasis is the main route of spread for endothelial carcinoma. Especially, partial and pelvic lymph node metastasis should happen earlier when the deeper endometrial invasion, more malignant degree, or worse histological grade existed, which will directly affect the result of therapy. Lymph metastasis firstly occurs in adjacent stroma of solid tumors in respect that tumor cells produce some tissue factors that can promote micro-lymphatic hyperplasia and hydrolyze stromal component, which will lead to the invasion and instant metastasis spread of solid tumors by lymph cycle.Vascular Endothelial Growth Factor-C (VEGF-C) is a specifically tissue factor in VEGF family, which can induce the formation of lymphatic. There is a strong correlation between... |
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