The Dependablity Research Of Maternal Serum Inhibin A And Abnormal Pregnancy

Section 1 Dependablity research between inhibin A and threatened abortionObjective : TO detect whether maternal serum inhibin A can predict the outcome of threatened abortion .Methods: serum inhibin A andβ-hCG concentration were determined by a solid quantitative sandwich enzyme immunoassay technique(Sandwich ELISA) both in threatened abortin group and controls, compare their statistical significances.Results: 6-7weeks of gestation serum inhibin A concentration of successful and failure pregnancy is 426.25±96.2 pg/ml, 11 7±32.5 pg/ml respectively. 8-9 weeks of gestation serum inhibin A concentration is 653.5±110.5 pg/ml and 264±26.8 pg/ml,these two is statistical significant,p is 0.0004and 0.001 respectively.Conclusions: Inhibin A can be a good biochemistry marker to prodict outcome of threatened abortion. Section2 The relationship between threatened abortion during first trimester and the pregnancy outcome in third trimesterObjective : To research whether threatened abortion during first trimester increases risk of pregnancy complications during third trimesterMethods: From 2005 August to 2006 July we collected experiment group (n=75)who worried about vaginal bleeding in first trimester meanwhile their embryos were confirmed viable with ultrasound .The control group (n=75)wasn't have vaginal bleeding in first trimester ,the two groups'mean age is no different.the two groups were follow-uped after labor , statistics and compare the differece between the pregnancy complications ,delivery andnewborn infant desease of two groups.Results: incidence rate of Pregnancy complication in threatened abortion group significantly increase than the control group,the complications are inevitable abortion, premature labor,premature rupture of membrane, hypamnion, preeclampsia, fetal growth restricted, P all less than 0.01;theothers : placenta praevia, gestational diabetes mellitus,fetal distress in uterus,umbilical core revolve body , fetal anomaly etc are impossible to arrive to a objective evaluation because of the few cases.Conclusions: we should look the threatened abortion is a high risk signal and think highly of it .because it can increase the risk of premature labor , premature rupture of membrane, hypertension syndrome of pregnancy, newborn infant abnormal body weight. Section3 dependablity reseach between maternal serum inhibin A concentration and the onset of preeclampsiaObjective : to reseach whether maternal serum inhibin A concentration would follow with the onset of preeclampsia in third trimester.Methods: collect 2005 September to 2006 August hospitalize patientsand devided into two groups:preeclampsia group (n=20);normal pregnancy group (n=20);the mean age and the gestational age of two groups have no different . Maternal serum inhibin A and inhibin B were determined by Sandwich ELISA . the data were recorded and compared their statistical significance.Results: inhibin A concentration in preeclampsia group is significantly higher than control group .Although inhibin B concentration is slightly higher than control group ,the difference hasn't statistical significance.Conclusions: it is inhibin A not inhibin B increased significantly in preeclmpsia women maternal .Maybe inhibin A can be a good endocrine marker to assit prediction of development of preeclmpsia.