The Relationship Of Placenta Growth Factor And Interleukin-10 In The Risk For Cardiovascular Events Of Acute Coronary Syndromes

Objective: The important link of ACS was the unstable Plaque followed by thrombus formation, which was closely correlated with inflammation reaction. Through the confer of concentration of Placenta growth factor(PLGF) and Interleukin-10 (IL-10), the clinic significance in risk stratification of ACS was debated, to the end that the cross-link of mediators of inflammation and mediators of anti-inflammation in patients with ACS.Method: Choosing 76 CHD patients. There are 62 ACS patients and 14 Stable Angina Pectoris (SAP) patients. ACS patients which including 26 ST-segment elevation myocardial infarction (STEMI) patients, 20 Non-ST segment elevation myocardial infarction (NSTEMI) patients and 16 Unstable Angina Pectoris (UAP) patients. In the same time 30 cardiovascular neurosis patients were selected. The concentration of PLGF,hs-CRP and IL-10 were measured by the method of enzyme linked immunosorbent assay (ELISA). We detected the risk of follow-up cardiovascular events(death,repeated infarction and emergent revascularization) during 30 days and 3 months, then the results were Statistics analyzed. Using the 13.0 SPSS soft ware to analysis, the chief statistical indexes are tested by test of normality and homogeneity test for variance, all statistical data are indicated with (x±S), compared with analysis of variance, the group comparison are tested with SNK-q; dependablity analysis used the linear correlation analysis. The two sides"P"less than 0.05 can be considered the observable differences.Result: 1,The serum level of PLGF,hs-CRP were higher in STEMI group and NSTEMI / UAP group than that of SAP group(P<0.01); compared with UAP /NSTEMI group, the concentration of serum hs-CRP were higher(P<0.01) ,but the concentration of IL-10 was lower in STEMI group and NSTEMI / UAP group than that of SAP group. 2,The risk of cardiovascular events were increased in patients with higher serum level of PLGF and hs-CRP, which was decreased in patients with higher serum level of IL-10 during 30 days and 3 months of follow-up. 3,Patients with low hs-CRP and high PLGF serum levels were at significantly higher risk than patients who had low levels for both hs-CRP and PLGF. 4,In patients with high serum level of PLGF, higher serum level of IL-10 suggested a lower risk for subsequent cardiovascular events. 5,There was a inverse correlation between the serum level of PLGF and IL-10, but no dependability between the serum level of PLGF and hs-CRP.Conclusion: 1,The serum inflammatory markers(PLGF,IL-10 and hs-CRP) were convincing in predicting risk stratification of ACS. 2,Compared with hs-CRP, PLGF was better in predicting the subsequent cardiovascular events. 3,Elevated serum IL-10 levels were not only associated with a more beneficial prognosis in patients with ACS, but also counteracted the impairment in in patients with ACS associated with increased PLGF serum levels. The balance between pro-inflammatory and anti-inflammatory mediators is a major determinant of outcome in patients with ACS.