Clinical Analysis Of Ulcerative Colitis

Objective Objective to study the clinical features of Ulcerative colitis disease(UC).Methods A retrospective analysis was performed in 290 in-patients with UC diagnosed in past 6 years. Results In the 290 patients, The ratio of male to female was 1.39:1. The mean age at the diagnosis was 44.29 years old, the common ages ranged from 30 to 59 years old, and the peak ages were from 30 to 39 years old. The typical clinical symptom of UC were diarrhea, bloody purulent stool and abdominal pain, showing few extra intestinal manifestations and severe complications. Inflammation in 290 UC cases mainly scattered aong proctitis or proctosigmoiditis was found in 107 (48.86%) cases. Endoscopic features included diffused congestive edema of intestinal mucosa, or widespread erythema, erosion and ulceration, the ratio of which was 88.9%,66.1%,respectively. Histological manifestations showed massive inflammatory cells infiltration in mucosa and submucosa, crypt abscess, erosion and ulceration. There was two cases developing colon cancer, ten cases moderate to severe atypical hyperplasia. Conclusions The major symptoms of UC are diarrhea, bloody purulent stool and abdominal pain. The lesions of UC are commonly located in the rectum, sigmoid colon, and endoscopic features included diffused congestive edema of intestinal mucosa, or widespread erythema, erosion and ulceration. Colonoscopy with histological manifestations is the very major means for the diagnosis of ulcerative colitis.