| Objective :The purpose of this study is to explore the effects of biofeedback therapy to Obsessive-compulsive disorder(OCD) patients by observed the change of biological maker and psychological marker in OCD patient which under the biofeedback therapy.Method:Fifty OCD inpatient and outpatients treated in our hospital met DSM-ⅳcriteria was randomly divided into trial group(male 11 cases and female 14 cases ) and control group(male 12 cases and female 13 cases).All subjects were treated with drugs therapy and Morita's therapy. Trial troup were treated with biofeedback therapy and control group were treated whith mimic biofeedback therapy(in the biofeedback therapy office,simi-reclining position,a half hour treatment ,record myoelectricity of frontal muscle,there is no cue word ,no background music).Included criterion:all patient met DSM-ⅳcriterion;the scores of Yale-Brown obsessive compulsive scale(YBOCS) is higher than 12 scales;age range from 15 to 45 years old.Exclude criterion:Subjects would be excluded when comorbid with substance abuse or other psychoses in acute phase;pregnant women ;or comorbid with severe heart , liver , kidney, and lung disease;or the subjects have severe intelligence deficit that can not understand the information of biofeedback therapy.Two steps were presented to the subjects,the first steps is measuring and recording all patients'scores of Hamilton's Anxiety Scale(HAMA) ,Hamilton's Depression Scale(HAMD) and Yale–Brown Obsessive Compulsive Scale (YBOCS) four times .After three months treatment the patients were overall assessment by patients themselves ,patients family members and doctor in charge of the patients.The assessment include the symptom decreased, society functional recovery, the amendment of interpersonal relationship and family relation.The second steps is collecting the biological marker.Trail group received biofeedback therapy.In the first course of treatment the subject received a progressive relaxation model therapy every one day for 8 times.And then start the second course of treatment that include 7 times of self-instructional training every one day a time.Control guoup subjects received mimic biofeedback therapy for 15 times every one day a time. All subjects were measured myoelectricity value and recorded it .And then start desensitization therapy two times a week. Two groups of subjects were presented with different therapy after desensitization therapy,trial group were treated with biofeedback therapy chracteristic by progressive relaxation ,control group were treated with mimic biofeedback therapy.16 times of desensitization therapy were completed in all subjects,stimulus intensity was raised gradually based on the patients tolerance.Mean myoelectricity values ,heart rate,blood pressure were mearsured and recorded before and after every time of desensitization therapy .All dates were analysis with SAS8 package,two-sample/group t-test.Result:Fifty subjects were included in this study(male 23 cases and female 27 cases).The age ,gender and cultural background, history ,drug and dose matched between two-group subjects.In the beginning of the test ,the myoelectricity value of two group has no significant difference,and after the treatment there were significant difference between two groups.There was no diffence of heart rate,blood pressure between two groups in the course of desensitization therapy.Compared with control group after one month treatment,the scores of HAMA in trial group is decreased remarkably,but the scores of HAMD and YBOCS were closer to those of control group .Two months treatment,there was no diffence in scores of HAMA,HAMD and YBOCS between two groups.Three months treatment ,the scores of YBOCS was significant difference between two group but the scores of HAMA ans HAMD have no difference.Symptom decreased and society functional recovery in trail group better than that in control group,but no diffence in interpersonal relationship and family relation between two group of overall assessment.Conclusion: OCD is a kind of anxiety disorder.the clinical feature of this disease is conscious self-compel exist with conscious self-anticompel that the patients suffering and anxiety .The symptoms of patient often appear after the relevant stimulus.So the key of treatment is the patients know how to deal with the stimulus,desensitization therapy play an important role in the treatment of OCD patients.But it may be cause the patient anxiety and agony,even impulsive behavior,some patients can not endure and give it up.It is a final conclusion that biofeedback therapy has good effect of anti anxiety.So in this study ,we reduce the subject's anxiety ,agony and potential impulsive behavior by using biofeedback therapy after desensitization therapy.Enough course of biofeedback therapy can decrease the patient anxiety .One month treatment the scores of HAMA in trial group significant lower than that in contro group,it is proved that the biofeedback therapy has the effect of anti anxiety again.In the course of desensitization therapy,the degree of agony of subjects of trial group were lower than that of control group,so the patients can endure the therapy better.After several desensization therapy ,the patients have the accomplishment feeling of conquer the symptom of disease,and improve the confidence of overcome the disease.In this study the stimulus intensity was raised gradually,then the patient have more ability endure the stimulus,at the same time the symptom is fewer than before.After three months treatment,the scores of YBOCS in trial group is significant lower than that in control group,it is proved that biofeedback therapy play an important role in treatment of OCD ,it can reduce the course of disease,have a better effect.In subjective view,all trial group subjects were willing to received biofeedback therapy,they feel relax and pleasant after treatment.It is easy to perform and self practice,it is safe and no side effect.In a word biofeedback therapy should bring into the conventional therapy of OCD and worth to extend.
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