The Effects Of Oxidized Low-density Lipoprotein On The Pathogenesis And Development Of Hypertension Disorders Complicating Pregnancy

Objective: To investigate the plasma level of oxidized low-density lipoprotein (ox-LDL) and deposition of ox-LDL on uteroplacental vessel wall, and explore the effection of ox-LDL on the pathogenesis and development of hypertension disorders complicating pregnancy to provide further theory evidence for its pathogenesis.Methods: The experimental subjects were divided into two groups: 23 cases with hypertension disorders in pregnancy (13 cases of gestational hypertension, 10 cases of pre-eclampsia and eclampsia), 15 cases of normal pregnant women were studied. The vascular lesions were determined by means of HE stain, detection the deposition of ox-LDL on uteroplacental vessel wall by immunohistochemistry and the plasma levels of ox-LDL by ELISA.Result: 1 HE staining showed the placenta small vessel wall of hypertension disorders complicating pregnancy was thicken and the fibrinoid necrosis of the wall was significantly higher.2 The deposition of ox-LDL on placental vascular walls were dyed yellow .In the cases of pre-eclampsia and eclampsia, there were intensity positive staining 2 cases , generally strong staining 5 cases, weak positive staining 3 cases. In the cases of gestational hypertension, there were generally strong staining 1 cases, weak positive staining7 cases and negative staining 7 cases. In the cases of normal, there were weak positive staining5case and negative staining 10 cases. The mean PI in pre-eclampsia and eclampsia group were (205±74), in gestational hypertension group were (85±32), in normal group were (75±29).3 The deposition of ox-LDL on placental vascular walls of pre-eclampsia and eclampsia patients were large, and were higher than that in gestational hypertension and normal (both p<0.01). Compared with normal, the deposition of gestational hypertension showed no signifance(p>0.05).4 The plasma levels of ox-LDL in pre-eclampsia and eclampsia group is (71.37±24.53ng/ml), significantly higher than that in gestational hypertension group (46.51±13.80ng/ml), and normal group (45.95±12.97ng/ml) (p<0.01). Compared with normal, the deposition of gestational hypertension showed no signifance(p>0.05).Conclusion: The plasma levels of ox-LDL and the deposition of ox-LDL on placental vascular walls of hypertension disorders complicating pregnancy were significantly higher than that in normal. Suggest the ox-LDL was damage the vascular endothelial function and through a series of mechanisms to promote the pregnancy-induced hypertension and the incidence of disease development.