The Study On Clinical Effect And Signal Transduction Related To The Impact Of Enzyme PLD With Busuishengxue Granule In Chronic Aplastic Anemia

Objective:To discussed the clinical effect of Busui Shengxue Granule(BSSXG) in treating chronic aplastic anemia(CAA) and observed the different in expression levels of PLD in CAA patients before and after treatment.reveal the pathogenesis of CAA and and effect mecheanism of supplement kedney herbs on CAA.Method:60 CAA patients were divided into experiment group and control group randomly in which 30 patients in the experiment group while 30 in another.The protein expression PLD in serum of cultured bone marrow stromal ceils was measured by Western blot.Result:1.The effect of Busuishengxue Granule was superior to that of Zaizaoshengxue Tablet(P<0.05),the curative effect of Yang deficiency type was superior to that of Yin deficiency type(P<0.05).2.The expression levels of PLD in CAA patients were lower than in the controlled group,Busui Shengxue granule can improve its level in different degree.Conclusion:1.The effect of Busui shengxue Granule to CAA was superior to that of Zaizao shengxue Tablet,the curative effect of Yang deficiency type was superior to that of Yin deficiency type.2.The Abnomal expression of PLD serum can affect the bone marrow haematopoiesis and is related closely to CAA.3.Busui Shengxue Granule inhibit the apoptsis of bone marrow hematopoietic stem/ progenitor cells by regulationing PLD which mediate the signal transduction pathway.Italsocan regulation the bone marrow hematopoiesis,increase proliferationand differentiation of hematopoietic stem/progenitor cells.