The Study On Clinical Effect And Signal Transd-Uction Related To The Impact Of Enzyme ERK5 With Busuishengxue Granule In Chronic Aplastic Anemia

Objective: To observed the clinical effect of Busui Shengxue Granule (BSSXG) i n treating chronic aplastic anemia (CAA) and the different effect in expression levels of ERK5 of bone marrow stromal cell.Method: 124 CAA patients were divided into experiment group and control group randomly in which 60 patients (off 1)in the experiment group while 63(off 2) in another. The protein expression levels of ERK5 in bone marrow stromal cells was measured by Western blot.Result: 1.The effect of Busuishengxue Granule was superior to that of Zaizaoshengxue Tablet(p<0.05), the curative effect of Yang deficiency type was superior to that of Yin deficiency type(p>0.05). 2.The expression levels of ERK5 in AA patients were lower than in the controlled group, Busui Shengxue granule can improve its level in different degree.Conclusion: 1.Busui Shengxue Granule (BSSXG) is a kind of drug to treat the CAA feasible and effective.2. Busui Shengxue Granule inhibit the apoptsis of cells by regulationing expression levels of ERK5 of bone marrow stromal cells which mediate the signal transduction pathway.And improve the cell proliferation and microenviroment of the hematopoietic for increase the recovery of bone marrow hematopoiesis.