The Effect Of Sports With Ganoderma Lucidum Pdysaccharides Against Diabes And The Influence Of Diabetic Liver Damage

Diabetes as a threat to human health, the endocrine metabolic disease is one of the three diseases cause death. Due to the complexity of the etiology of diabetes and many factors, disease pathogenesis of diabetes is unclear, so for the treatment of diabetes also cannot fundamentally solved. In recent years, the material has confirmed that insulin resistance is the main characteristics of diabetes, liver, plenty of insulin receptor, can nourish hepatic insulin, will make metabolic harmful substances accumulation, further damage liver cell, make its energy supplies mitochondrial damage, protein synthesis of activity decline ribosomes, liver of protein synthesis. Research found that diabetes, liver ALT (alanine amino transferase), the AST (l-aspartic acid amine transferase), nitric oxide (abnormal) indexes, such as insulin is closely related with the metabolic abnormalities.Exercise therapy for diabetes caused the role of more and more attention of scholars, various research shows that sports can improve insulin sensitiity, causative agent can control the illness development as well as the prevention of complications. In Chinese medicine, especially for many experts also explores the effective prevention of diabetes drugs.By means of ganoderma lucidum polysaccharides sports, discusses the prevention of diabetes, the study of the liver, etc, the AST ALT role in diabetes metabolic disorder in the liver, MDA and SOD the antioxidant capacity. Aimed at exploring an effective prevention of diabetes and feasible method for developing diabetes food accumulate beneficial material.50 Wistar will only male rats, random out 10 as control group (N), the residual 40 for diabetes model group. According to the model group 50mg/kg weight control STZ injected rapidly celiac, intraperitoneal injection of animal water-volume 0.1% folic acid salt buffer. Only after a successful modeling selected randomly divided into diabetes, 32 (D), quiet diabetes drug group (DG), diabetes in the exercise group (DS), diabetes, sports dosing group (having). DS group and group DSG having six weeks of continuous training, six days a week. DG group and group having daily lavage ganoderma lucidum polysaccharides measurement 200mg/kg, served with the volume control irrigation distilled water, lasting seven weeks. Observe and weight, fasting glucose intervention (FBG) and following the interention triglycerides (TG), serum insulin (Ins), saccharification serum protein (GSP), liver, and NOS transaminase, and the content of MDA and SOD.Results: take celiac rapid injection (50mg/kg) STZ method, can successfully established accord with human diabetes characteristics of Wistar rat model. The model group and control group (N) compared with normal blood glucose, and increased differently, weight reduction (P < 0.01). After feeding medicine and 6 ZhouZhengGui after training, (1) medicine group (DG), in the exercise group (DS) and dosing group (having) of blood sugar and glycated triglycerides, serum protein, and liver tissue of aminotransferase and MDA content were significantly lower than diabetes quiet, While serum insulin and liver SOD, higher content of diabetes quiet group (P < 0.01). (2) in three diabetes, movement of the intervention group dosing group (having) and medicine group (DG) fasting glucose values are lower than in the exercise group (DS), sports dosing group (having) fasting glucose values (DG) than medicine group (P < 0.05). Sports dosing group (having) serum insulin levels higher than in the exercise group, medicine group (DG) Ins level than exercise group (DS), sports dosing group (having) Ins level than medicine group (DG) (P < 0.05). In comparison, the content of SOD sports dosing group (having), medicine group (DG), in the exercise group (DS) less (P < 0.05). In the saccharification serum protein, triglyceride and liver tissue aminotransferase and MDA, comparison, sports dosing group (having) minimum, medicine group (DG), in the exercise group (DS) higher (P < 0.05). Conclusions: (1) of Wistar rats through a rapid injection, can STZ intra-abdominal diabetic rats successfully established model (80%), the rate of modeling for diabetes research laboratories provide premise. (2) three different intervention group of diabetes, diabetic rats blood sugar and liver injury recovery has a positive impact. (3) results show that sports ganoderma lucidum polysaccharides for diabetic rats blood sugar, triglycerides, saccharification serum protein, liver and reduce serum Alt activity of insulin, liver SOD level is most obvious (P < 0.05), and is superior to the single drug or movement.