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The Effects Of Early Swimming Exercise On The Immune Function In The Overfeeding Rats

Posted on:2011-12-25Degree:MasterType:Thesis
Country:ChinaCandidate:L K NiuFull Text:PDF
GTID:2167360305480905Subject:Human Movement Science
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Purpose: Children's obesity has become an important public issue which seriously affects children and adults'health. No matter in developed or developing countries, there is a certain rise on obesity and overweight rates in children.Obesity can reduce children's fitness and resistance which would lead to an increase on susceptibility of many diseases. As we all know, children's obesity not only affect health in childhood , but also in adulthood. Foreign studies of fifty years'follow survey have shown that 30% obesity in childhood would last to their adulthood, and their disease morbidity and mortality of cardiovascular was significantly higher than patients with obesity in adulthood. Obesity problem is laso the issue in the study of endocrine diseases in China. Based on epidemiology of children's obesity and metabolic abnormalities, there has been many systemic and deep studies. Lots of information has showed that there was an increase trend on obesity in under seven- year-old children. And the trend was the highest in city, higher in urban than in country. Obesity rate was the highest in less than six-month-old baby and then lowered to a minimum at two-year-old , and it rose to maximum at seven-year-old. Some studies has showed that obesity rate was higher in men than in women during the adolescent period. There was obvious gender differences adolescent obesity. And study of tratified random and cluster sample's survey has showed that there was 85.4% obesity in children under fourteen-year-old which suggested prevention of obesity should be made before fourteen during sudden and increase period of puberty.Based on theory of immunology and impact of sports and obesity on immune system, this paper made a observation of early swimming exercise of young rats with excessive food on immune function. It focused on, after intervention of swimming exercise during growth period, immune organs in rats'spleen and thymus, blood in the relevant indicators of immune cells and the change of immunoglobulin IgG , IgM complement C3 ,C4 to compare intervention effect of different critical periods between embryonic period and the post-weaning growth period. It also evaluated the role of prevention and improvement on early exercise in immune dysfunction by obesity. It would lay a foundation for deep mechanism study and provide a new way for prevention by exercise in children's obesity and related diseases.Research Methods: The study objects were 16 SD female rats, weight 270±6g of clean grade and 8 SD male rats, weight 350±5g. Put them together and after pregnancy, divided the pregnant rats into pregnancy quiet group and pregnancy swimwing group. The pregnancy swimwing group swam from pregnancy to childbirth, they had swimming training of 10min/day for six days a week. After childbirth, offspring by pregnancy quiet group divided into normal feed group (YN Group) and over feed group (YS Group). And offspring by pregnancy swimwing group divided into swimming during pregnancy (YSE Group ), 3 weeks'swimming after weaning group (YSE1 Group) and 7 weeks'swimming after weaning group (YSE2 Group). There was eight rats in each group. For YSE1 Group and YSE2 Group, there were weekly increments'swimming exercise for six days a week. After seven weeks, all the rats of five groups were made. It weighed thymus and spleen to calculate the corresponding index. It observed changes of blood by automatic routine blood testing. It also measured erum immunoglobulin IgG, IgM and complement C3, C4 levels by immune turbidimetric ending method and rate nephelometry.Results: 1.The serum IgG and complement C3 was significantly lower in YS Group than that in YN Group(P<0.01) , and platelet count was significantly higher in YS Group than that in YN Group(P<0.01). 2. White blood cell was significantly higher in YES Group than that in YS Group and YN Group(P<0.01), serum IgG was significantly lower in YES Group than that in YN Group(P<0.01), but was significantly higher in YES Group than that in YS Group(P<0.01). And serum IgM, complement C3, C4 were significantly higher in YES Group than that in YS Group and YN Group(P<0.01). 3. Platelet and serum IgG were significantly higher in YES1 Group than that in YES Group(P<0.01). White blood cell, serum IgM and complement C3 were significantly lower in YES1 Group than that in YES Group(P<0.01). And Platelet and serum IgG were significantly lower in YES2 Group than that in YES Group(P<0.01). White blood cell, serum IgM and complement C3 were significantly higher in YES2 Group than that in YES Group(P<0.01).Conclusion: 1. Over-feeding methods could lead to an decrease on immune function in young rats. 2. Swimming exercise during embryo period could improve immune dysfunction by over-feeding. 3. Exercise during early period could further enhance the effect on immune function in rats by exercise during embryo period.
Keywords/Search Tags:over-feeding, swimming, immune function, IgG, complement C, IgM
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