Liver And Stomach Treatment Of Functional Dyspepsia (hepatogastric Card) Clinical Research

Objective:To explore the therapeutic effect of soothe liver and regulate stomach method in treating functional dyspepsia ( FD ). Methods: 60 cases of FD were divided into two groups randomly.The treatment group ( 30 cases ) was treated with the primary decoction orally and the control group ( 30 cases ) treated with motlium orally.The treatment course of both groups was 4 weeks. The clinical effects were observed during and after the course. Gastric emptying and small intestinal transit time were measured by means of radiopaque markers in 30 patients (the treatment group14 / control group 16) pretreatment and posttreatment. Results: (1)The clinical effect: In the treatment group, 18 cases recovered, 4 cases significantly improved, the effectual rate is 70.33%; 4 cases improved, the total effective rate in the treatment group is 86.67%. In the control group, 10 cases recovered, 4 cases significantly improved, the effectual rate is 46.67%; 5 cases improved, the total effective rate in the control group is 63.33%. There was statistically significant difference in the total effective rate between the treatment group and control guoup(P<0.05).The patients in treatment group reported their syndrome of traditional Chinese medcine score markedly decreased at the end of two week or four week ( 19.14±5.86 pretreatment vs 10.05±4.71,5.87±3.02,P<0.01 ) , and traditional Chinese medicine could significantly improve the symptoms including early satiety , abdominal distention , epigastric discomfort, eructation and nausea.After four weeks' treatment,the percentage of symptom-free of abdominal distention,epigastric discomfort,pain in Chest and Hypochondrium,anorexia is above 60%,and the percentage of symptom-free of gasgralgia,nausea and vomiting is also above 40%. (2)The condition of the gastric emptying: After four weeks' treatment,the half or full gastric emptying of patients in treatment group were markedly shortened (0.55±0.20h,1.12 ± 0.40h respectively),there were statistically significant difference between pretreatment and posttreatment (P<0.05).The time of the half or full gastric emptying of patients in control groups were shortened (0.60 ± 0.15h , 0.92 ± 0.11h respectively).There were also statistically significant difference between pretreatment and posttreatment(P<0.05).But there was not statistically difference between the treatment group and control guoup(P>0.05).(3)The condition of the small intestinal transiting time:The treatment group can promote intestinal movement and the small intestinal transiting time of patients also were significantly shortened (0.98±0.10h).The control group has no influence on the small bowel transit time.Conclusion: The method of liver-soothing and stomach-regulating has obvious therapeutic effect on FD. The mechanism might be related to adjusting gastrointestinal hormones and modulating gastrointestinal motility.