Clinical Study On The Treatment Of Functional Dyspepsia By Soothing The Liver And Stomach And Its Effect On Gastrin

Objective: The purpose of this study was to observe the effect of Shugan Hewei recipe on the clinical efficacy and gastrin in patients with discordant functional dyspepsia of liver and stomach,so as to provide the basis for the clinical application of this prescription in the treatment of FD.Methods: 67 patients with functional dyspepsia and disharmony of liver and stomach were randomly divided into treatment group(n=34)and control group(n=33).The patients in treatment group were treated with self-made prescription of soothing liver and stomach,and 67 patients with functional dyspepsia were divided into two groups: treatment group(n=34)and control group(n= 33).The control group was treated with mosapride citrate for 4 weeks.Two groups of patients before and after treatment of TCM syndrome,anxiety and depression status score and clinical efficacy were compared;At the same time,the changes of gastrin indexes,adverse reactions and recurrence rate before and after treatment were observed.The collected data were analyzed by statistical software.Results:1.Comparison of TCM syndrome curative effect: 1 comparison of total effective rate and healing rate: the total effective rate of treatment group(Shugan and Wei Fang)and control group(mosapride citrate)were90.00%,76.67% and 66.67%,respectively,and the total effective rate of treatment group(liver and stomach prescription)and control group(mosapride citrate)were 90.00%,76.67% and 66.67%,respectively.30%;The total effective rate and healing rate of the two groups were compared,the treatment group was superior to the control group,the difference was statistically significant(P<0.05).2 comparison of the total integral of TCM syndrome: intra-group comparison,After treatment,the total score of TCM syndrome in the two groups was significantly lower than that before treatment(P<0.01).Comparison between groups,total syndrome of traditional Chinese medicine after treatment in the two groups The scores in the treatment group were significantly lower than those in the control group(P<0.01).2.Comparison of single symptom curative effect: 1 main symptom:after treatment,the scores of gastric distension and flank fullness in the two groups were significantly decreased(P<0.01),and there was no significant difference between the two groups(P<0.05).Compared with the control group,the treatment group was significantly lower than the control group(P<0.01).There were significant differences between the two groups in symptoms after treatment(P<0.01),such as irritability and irritability,sighing,and reduction of gastric absorption(P<0.05),and the difference was significant between the two groups(P<0.05).On the other hand,there was no significant difference between the two groups(P>0.05)in the scores of symptoms of upper abdominal burn and nausea and belching(P>0.05).3.Comparison of gastrin(GAS)level: after treatment,the GAS of the two groups was lower than that before treatment,the difference was statistically significant(P<0.05).The level of GSA in the treatment group was lower than that in the control group,and there was a significant difference in the GAS level between the two groups after treatment(P<0.01).4.Comparison of 4.HAMD scale and HAMA scale: after treatment,the HAMA scale and HAMD scale score of the two groups decreased compared withthose before treatment,the difference was statistically significant(P<0.01).The scores of Hamma and HAMD in the treatment group were lower than those in the control group.After treatment,the scores of Hamd and HAMA in the treatment group were significantly lower than those in the control group(P<0.01).5.Comparison of recurrence rate: After 3 months of treatment,the total recurrence rate of the treatment group and the control group was11.11% and 34.78%,respectively.The difference between the two groups was statistically significant(P<0.05),and the long-term effect of the treatment group was better than that of the control group.6.Drug safety assessment: no adverse reaction was found in both groups during the treatment,and no significant abnormality was found in the safety index.Conclusion: Shugan and Wei prescription can effectively reduce the clinical symptoms of patients with functional dyspepsia of liver-stomach disharmony,improve the anxiety and depression state of patients,and no adverse reactions are found,the recurrence rate is low,and the serum gastrin level of patients is decreased.It is worthy of further clinical research and promotion.