Chronic renal failure is the result of renal damage and evolutional depravation caused by all kinds of pathogeny.At present there is no perfect treatment to CRF,especially for terminal patients,who can only rely on dialysis or kidney transplant to live on.So the sticking point is diagnosing and treating CRF in a early stage,staving the renal function to get worse,in which aspect, traditional Chinese medicine(TCM) has a compelling achievement.On the basis of inheriting and packing up the experience of several generations of famous TCM doctors in treating CRF,the renal medicine department of Guang'an men hospital bring forward supplementing qi and invigorating blood circulation,dispelling dampness and excreting turbid method in treating CRF(kidney deficiency turbid retention syndrome),and found strengthening zheng eliminate turbid solution, supplementing qi excreting turbid capsule as the internal hospital treatment,which made a preferably effect.This study is to further evaluate the clinic effect of supplementing qi and invigorating blood circulation,dispelling dampness and excreting turbid method in treating CRF(kidney deficiency turbid retention syndrome) via clinic trial.Objective:To evaluate the clinic effect of supplementing qi and invigorating blood circulation,dispelling dampness and excreting turbid method in treating CRF(kidney deficiency turbid retention syndrome).Method:use random,open,positive drug parallel comparison clinic research method.Nonage and metapfase of CRF:Treatment group and contrast group has 25 cases respectively.On the basis of diet control and allopathy,the treatment group take trengthening zheng eliminate turbid solution orally 20 ml tid.The contrast group take niaoduqing grain 5g tid,every morning,noon,evening,and 10g before sleep.The period of treatment is 8 weeks.Metapfase and telophase of CRF: Treatment groupand contrast group has 25 cases respectively.On the basis of diet control and allopathy,the treatment group take upptementing qi excreting turbid capsule orally 2.4g(4 grains) tid.The contrast group take niaoduqing grain 5g tid, every morning,noon,evening,and 10g before sleep.The period of treatment is 8 weeks.Results:Strengthening zheng eliminate turbid solution:(1)The disease synthetical effect:8 weeks after the treatment,the two groups have no statistics diversity(p>0.05).(2) TCM syndrome effect:8 weeks after the treatment,the two groups have statistics diversity in TCM syndrome total integral(p<0.05),but there is no statistics diversity in TCM synthetical effect(p>0.05).(3) Main experimental indexes comparison:the serum creatinine of the treatment group ascends significantly(p<0.05),the rest experimental indexes have no statistics diversity fore-and-aft treatment,or within the group.The serum creatinine of the contrast group ascends significantly,and Ccr decreases significantly(p<0.01),the rest experimental indexes have no statistics diversity fore-and-aft treatment,or within the group.Supplementing qi excreting turbid capsule:(1)The disease synthetical effect:8 weeks after the treatment,the two groups have no statistics diversity(p>0.05).(2) TCM syndrome effect:8 weeks after the treatment,the two groups have statistics diversity in TCM syndrome total integral(p<0.05), the treatment group has significantly lower TCM syndrome total integral than the contrast group,but there is no statistics diversity in TCM synthetical effect(p>0.05).(3) Main experimental indexes comparison:all the experimental indexes have no statistics diversity fore-and-aft treatment,or within the group(p>0.05).Conclusion:The clinic effect of strengthening zheng eliminate turbid solution in treating nonage and metapfase of CRF resembles the clinic effect of niaoduqing grain.The clinic effect of supplementing qi excreting turbid capsule in treating metapfase and telophase of CRF resembles the clinic effect of niaoduqing grain. |