| Background:Myocardial mitochondrial energy production is the main place, after endurance training with different intensities, some oxidation of some mitochondrial enzymes and antioxidant enzymes in your organization will have different Adaptive changes, thus affecting the energy metabolism of cells. Cardiac function and myocardial energy metabolism, and adaptive changes of myocardial energy metabolism is the focus of sports scientific research, is in the study of energy metabolism of myocardial cells mitochondria of hot spots and key points. Currently study on myocardial energy metabolism in different sports there are more, but most are from mitochondrial antioxidant capacity, camp after exercise (ATP, and ADP, and AMP), mitochondrial respiratory chain oxidase activity and unilateral conduct a study on heart function. And the relationship between them is how to contact, if there is a direct correspondence between, sport training effect on the relationship between them is what, also deserve our further discussion.Purpose:1 motion Adaptive changes of heart function in rats, primarily from changes in antioxidative defense system to explore its primary mechanism.2 from the probe into the changes of energy metabolism in motion-Adaptive motion-adaptive mechanisms of heart function.3 explore motion Adaptive changes of mitochondrial energy metabolism-to increase the antioxidant activity of myocardium.Method:this article reference Bedford reported of large rats maximum photo oxygen volume of standard developed different strength of endurance training programme, observation movement training on large rats myocardial of glands Glycoside acid content and can load (EC), respiratory chain oxidation enzyme (NADH and CCO), and anti-oxidation enzyme (SOD, and GSH-PX), and fat mass peroxide (MDA) and heart function of changes, discussion different strength of endurance movement training on myocardial energy metabolism of effect law, and anti-oxidation defense ability and heart function of effect, from energy metabolism, and anti-oxidation angle stated different strength of endurance movement on heart function of effect. 40 SD reference Bedford reported in female rats of maximum oxygen uptake in rat standard, establishment of large, medium and small of different intensity exercise in rats model; at the same time setting of the control group. In training end determination the group large rats of heart function, acute processing mining myocardial organization sample to observation myocardial mitochondrial within glands Glycoside acid (ATP, and ADP, and AMP) and its respiratory chain enzyme activity (cell pigment c, and NADH oxidation enzyme) of changes and its anti-oxidation ability (MDA, and SOD, and GSH) of changes, and discussion movement heart function changes and myocardial mitochondrial energy metabolism changes Zhijian of relationship, and the myocardial mitochondrial energy metabolism movement adaptability changes of mechanism.Results:(1) large rats after movement training, three a movement group of heart rate relative below quiet group, and in the strength group below quiet group has significantly sexual differences (P<0.05), although small strength Group HR also below quiet group, but and no statistics significance, HR in large strength group of when recovery to quiet level; three a movement group of LVSPP, and±dp/dtmax relative than quiet group, apart from small strength more quiet group has significantly sexual differences (P<0.05) outside, in the, and large strength group more quiet group has very significantly sexual differences (P<0.01); and three a movement group of LVEDP relative below quiet group, small, and in the strength Group significantly below quiet controlled group (P<0.01), large strength group slightly than small strength group, but overall also is below quiet controlled group, and has significantly sexual differences (P<0.05).(2) after training, the rats, myocardial ATP, ADP, and AMP content is higher than the quiet group. After small strength training ATP, and ADP and AMP content are has than quiet controlled group, but does not with statistics significance; in the strength training three who more quiet controlled group has very significantly sexual differences (P<0.01); large strength training, three who content also is significantly than quiet Group (P<0.05); can load of changes and ATP of changes consistent, in the, and large strength Group respectively more quiet group has significantly sexual differences (P<0.01, and P<0.05).(3) after training, the rats, NADH, CCO content above a quiet group of cardiac, and quiet strength groups compared to control groups, NOX, COX difference is significant (P<0.01). Changes of cardiac NADH and CCO is strength in group> small strength group> high-intensity group> quiet group. (4) large rats by training, in the, and large strength movement group myocardial of SOD content are significantly than quiet group, large strength group although slightly below in the strength group, but and quiet group compared exists significantly sexual differences (P<0.05), small strength group SOD content although than quiet group, but and no statistics significance; and quiet controlled group compared, in the, and large strength group GSH differences has very significantly sexual (P<0.01); myocardial of MDA and quiet controlled group compared, small, and in the strength group differences and no significantly sexual, and large strength group differences significantly (P<0.05). Strength in the myocardial changes of GSH and SOD is group> small strength group> high-intensity group> quiet group of gastrocnemius muscle strength in GSH group> small strength group> high-intensity group> quiet group, changes of MDA is high-intensity group> quiet group> strength group> strength of small groups.Conclusion:(1) intensity endurance training in rats produced a good adaptation, systolic and diastolic function of the heart is enhanced.(2) medium-intensity endurance training increases myocardial Adenylate, respiratory chain oxidase (NADH and the CCO) content, energy metabolism level be strengthened.(3) medium intensity resistance training improve cardiac activity of antioxidant enzyme SOD, GSH, increasing the ability of antioxidant defense system of myocardial can effectively remove the MDA, protect cells from free radical attack; high-intensity endurance training for a long time will reduce the antioxidant activity of myocardium, MDA generates increased biofilm injury increased decline in cell function.(4) moderate intensity endurance training increases myocardial Adenylate, respiratory chain oxidase (NADH and the CCO) content, energy metabolism levels be strengthened, while cardiac function in enhancing; long mitochondria injury induced by high intensity endurance training, reducing the decline of energy metabolism of myocardial cells, thereby reducing cardiac function.(5) through antioxidant effects of suitable strength endurance training is to improve energy metabolism, enhance cardiac function, and intensive endurance training reduced antioxidant capacity and energy metabolism is stifled, affect cardiac function. |
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