Clinieal Observation Of Injection Safflower Yellow Pigment On Treating Stroke Blood Stasis Syndrome(Cerebral Infarction)

PurposeWith the injection of safflower yellow pigment grain, danshen injection TCM syndrome differentiation in stroke treatment with blood stasis syndrome (cerebral infarction), through the observation of safflower yellow pigment grain and salvia miltiorrhiza stroke clinical, syndromes signs score change, neural function defect degree change and the change of blood rheology, evaluation is the effect for activating blood circulation and eliminating stasis given by injection of safflower yellow pigment grain treatment with TCM syndrome differentiation stroke blood stasis syndrome (cerebral infarction) clinical curative effect, observe the curative effect is better than that of salvia miltiorrhiza injection, discusses whether the drug should be used in the syndrome differentiation intravenous administration of traditional Chinese medicine.Method1. The clinical data collection60cases of cerebral infarction patients (both for the hubei province hospital nerve internal medicine clinic in hospital and in March2011to January2012issued), Chinese medicine dialectical stroke of blood stasis syndrome. A parallel, randomized method, divided into injection of safflower yellow pigment with meat group (hereinafter referred to as the red flower group)30cases and salvia miltiorrhiza injection group (hereinafter referred to as salvia miltiorrhiza group)30cases, then in order to medicine. Of safflower yellow pigment grain groups:for zhejiang yongning pharmaceutical Co., LTD.(the batch number for Z20050146) production with the injection of safflower yellow pigment grain100mg join0.9%sodium chloride injection of250ml static drops, and, once the first14days. Salvia miltiorrhiza group:to chiatai qingchunbao pharmaceutical Co., LTD.(the batch number for Z33020177) production of salvia miltiorrhiza20ml to join250injection m10.9%sodium chloride injection static drops, a day once, a total of drug use14days, both groups were not set up its early. The healing process60cases are related to the foundation treatment, symptomatic treatment (such as adjust blood pressure, blood sugar, electrolyte, etc), the brain is not nutrition metabolic drugs or protectants, brain metabolism activator and similar drugs test of traditional Chinese medicine drugs.2. The doctor will first, after1,14days of stroke clinical performance rating, stroke syndrome signs score, neural function defect degree score, head CT or MRI each observation records a and fill in the form, and do statistics processing, comparison of safflower yellow pigment grain and salvia miltiorrhiza injection clinical curative effect.3. The hospital in the first, after each day14do a below laboratory: hematuria dung three conventional power field inspection, dung, blood rheology, liver and kidney function, head CT or MRI, electrocardiogram, blood prothrombin time and so on Stat i st i callyRanked data Ridit analysis, measurement data, the t test, count data using the X2test.Result(1) the clinical symptoms of stroke to determine:safflower yellow pigment group clinical recovery after treatment, the number one cases, effective number of13cases, the effective number of13cases, the total effective rate of90%; Salvia group that were the number of10cases, the effective number of13cases, total effective rate was76.67%. Statistically test the efficacy of treatment in both groups a significant difference (P<0.05), safflower yellow pigment can significantly improve the clinical symptoms of stroke.(2) traditional Chinese medicine syndrome signs determine the efficacy of:safflower yellow pigment group after treatment markedly the number of14cases, the effective number of13cases, total effective rate of90.00%; Salvia group that were11cases, the effective number of12cases, The total effective rate was76.67%, the statistical tests, significant differences (P<0.05). Safflower yellow pigment of traditional Chinese medicine syndrome has obvious signs of improvement effect.(3) The main symptoms, physical signs、neurological deficit scores. Hemorheology:statistical tests, significant differences (P<0.05), safflower yellow pigment group significantly.ConclusionThe treatment effect of Injection of safflower yellow group is significant for group salvia miltiorrhiza. That should also be selected medicine dialectical used in traditional Chinese medicine in the intravenous administration. And through the safety index of observation, shows two groups of medicine is safe.Problems:because of the total number of this topic only60cases, each group of30cases, belongs to a small sample comparison, still needs further clinical observation.