The Clinic Research Of The Method "Yangyinqinrehuoxue" To Prevent The Patients With UA From Taking Place Cardiovascular Events And RS After PTCA

【Background】Coronary atherosclerotic heart disease(CHD) is one of themain diseases menacing human’s health, the disease incidence and mortalityrate are continually rising, whereas unstable angina pectoris (UA) may havepoor prognosis, the risks of recent death and myocardial infarction are ratherhigh. The percutaneous transluminal coronary angioplasty has been one of theimportant technical methods to cure CHD. However. the restenosis (RS) andthe recent incidence of cardiovascular events in patients with atherothromboticdiathesis after PTCA remain difficult problems to the clinical doctors. Thisresearch puts forward the treatment principle of "Yangyin Qinre Huoxue" totreat UA and prevent and treat RS after PTCA not only on the basis of modernmechanism (the inflammatory reaction, the formation of thrombus), clinicalcharacteristics and pharmacology experiments of UA but also on the basis ofclinical documental reports. In this research we select MaiLuoNing asrepresentative drug to carry out theory and clinical practice study as well as toinvestigate the clinical curative effect and the possible function mechanism ofthe principle "Yangyin Qinre Huoxue" to cure UA.【Purpose】Primarily evaluate the position and function of the method"Yangyin Qinre Huoxue" to prevent UA (XiongBiXinTong) from taking placecardiovascular event and RS after PTCA. Discuss the new therapeutic method ofPectoral Stuffiness Pain and heartache.【Methods】The multicenter randomized, controlled study was conducted inthis research. 190 patients with unstable angina pectoris are randomly dividedinto two groups, one is control group(standard curing set) and the other istreatment group (standard curing+MaiLuoNing set). each group is divided intotwo parts by carry PTCA or not, and the two parts are studied respectively. Thetherapeutic course of the first part is 48 hours, and the aim is to observe theincidence of cardiovascular events in 48 hours; In the second part, thetherapeutic courseis is 15 days, and the aim is to observe the occurrence rate of RS in six months.【Result】The first part result is that after curing the treatment group’s clinicaltotal effective rate was 95.8% and obvious effective rate was 9.5%. Thetreatment group obviously surpassesed the matched control group (P＜0.05). 3cases needed emergent PTCA in the treatment group, while 9 cases neededemergent PTCA、one case occurred AMI、one case died in the control group. Theincidence of acute cardiovascular events in the treatment group was lower thanthe control group(P＜0.05). 49 cases in each group enter into the second part, sixmonths later, one case needed PTCA again、one case died in the treatment group,5 cases needed PTCA again、2 cases occurred AMI and one case died in thecontrol group, among which 2 cases of RS were diagnosed preoperatively bycoronary angiography. The incidence of acute cardiovascular events after PTCAin the treatment group was lower than the control group(P＜0.05).【Conclusion】Through this research, we have primarily evaluated the positionand function of the method "Yangyin Qinre Huoxue" to prevent UA(XiongBiXinTong) from taking place cardiovascular event and RS afterPTCA. "Yangyin Qinre Huoxue" is an important treatment principle that preventsUA patients from taking place cardiovascular events and RS after PTCA and alsoobviously alleviates the clinical symptoms of patients who suffer from PTCA.