Qi Huoxuetongmai Recipe Improve Observational Studies In Patients With Angina Artery Endothelial Function

ObjectiveTo explore coronary heart disease patients with stable angina pectoris (SAP) lesion counts and cardiovascular disease risk factors of Flow mediated endothelial diastolic dysfunction (hereinafter referred to as the Flow function of vascular endothelium cell mediated asodilation FMD).Observation of traditional Chinese medicine yiqi huoxue unclogged arteries (NaoXinTong capsule) the formulas related risk factors in patients with SAP, deficiency of blood stasis and the influence of the endothelial function of protection.MethodsCollected in November2011to July2011in dongzhimen hospital heart of74cases of SAP with qi deficiency and blood stasis syndrome patients, according to random number table method according to the order to the patient were divided into treatment group (that is, the foundation of western medicine treatment of qi and jiayi)(that is, the only basis of western medicine therapy) and control group, two groups of basic western medicine treatment are strictly conventional coronary heart disease and ZhiJiaShu after treatment, the treatment group in conventional coronary heart disease (CHD) before and after treatment on the basis of the other oral ZhiJiaShu NaoXinTong capsule (xianyang step pharmaceutical)4,3times a day.The control group only with strict routine treatment after coronary heart disease and ZhiJiaShu, observe the12weeks, and avoid the use of yiqi huoxue during treatment control group class unclogged arteries or proprietary Chinese medicine Chinese traditional medicine. Observed two groups of patients before and after the treatment of blood pressure, blood sugar, blood fat, platelet aggregation rate, high-sensitivity c-reactive protein, FMD and6-keto-P F1a NaoXinTong cytology test index changes.Results1. The SAP patients with single lesion group medicine before FMD is more than double branch lesions, the three lesion group, the difference was statistically significant (P<0.05), but the double branch lesions and pathological changes of three group medicine before FMD difference has no statistical significance (P>0.05).2. The drug before SAP patients blood sugar, LDL, HDL, TC, TG, uric acid, high-sensitivity c-reactive protein, platelet aggregation degree of eight indexes and FMD multivariate linear regression analysis, FMD and negatively correlated with platelet aggregation degree, the regression equation for FMD (%)=6.9440.303x platelet aggregation degree.3. Two groups of FMD is before treatment were significantly increased after treatment, the difference was statistically significant (P<0.05), but the comparison between the two way, there was no significant difference (P>0.05).4. The treatment group after treatment than before treatment high-sensitivity c-reactive protein significantly decreased, and the treatment group after treatment with normal serum cardiac microvascular endothelial cells co-culture cell secretion after6-ketone levels rose significantly, the difference had statistical significance (P<0.05), the control group after treatment platelet aggregation degree is significantly increased before treatment, the difference was statistically significant (P<0.05), the treatment group and control group after treatment the blood sugar, LDL, HDL, CHO before, TG, uric acid treatment had no obvious improvement, there was no significant difference (P>0.05).5. The two groups after treatment of angina, improve performance has improved (P<0.05), the treatment group after treatment symptoms of fatigue, shortness of breath, weakness of traditional Chinese medicine (TCM) three god has improved compared with before treatment, the difference was statistically significant (P<0.05).6. Single lesion, the double branch lesion group FMD after treatment than before treatment were significantly higher, the difference was statistically significant (P<0.05), FMD double branch lesions in Chinese traditional medicine group after treatment was obviously higher, the difference was statistically significant (P<0.05), the western medicine group after treatment PAgT was obvious rise, Chinese traditional medicine group before and after treatment the PAgT difference compared with the western medicine group with significant difference (P<0.05), three lesions in Chinese traditional medicine group PAgT difference before and after treatment and the rate of change were significant difference compared with western medicine group (P<0.05).Conclusion1. There may be a count in patients with coronary heart disease of coronary lesions, the more the trend of the vascular endothelial function, the worse, and vascular endothelial diastolic dysfunction FMD and negatively correlated with platelet aggregation degree.2. Yiqi huoxue unclogged arteries can improve the formulas SAP patients with angina pectoris and shortness of breath, fatigue, weakness of traditional Chinese medicine (TCM) three god symptoms.3. Both treatment group and control group all can improve endothelial diastolic function in patients with SAP, and yiqi huoxue flux pulse treatment can reduce the formulas high-sensitivity c-reactive protein in patients with SAP, platelet aggregation degree.