Expression Of TARC And MDC In Allergic Rhinitis And Its Clinical Significance

Objective: To determine the level of macrophage-derived chemokine(MDC、CCL17) and thymus and activation regulated chemokine(TARC、CCL22)in serum ofpatients with allergic rhinitis(AR), and discuss their role and clinical significance.Methods:60cases of specimens is selected，including the patients with30casesof allergic rhinitis(AR)15cases of non-allergic rhinitis（NAR） patients and15casesof healthy volunteers. ELISA was applied to assay the chemokines of CCL17andCCL22.Results: High level of CCL17and CCL22was detected in the AR patients,which was significantly different from that of NAR and healthy people. Serum levelsof chemokines CCL17in AR, NAR and healthy subjects was detected for673.10±39.11、611.31±13.51、604.54±12.23. Serum levels of chemokines CCL22inAR, NAR and healthy subjects was detected for820.62±51.32、722.68±25.99、702.18±22.75. Concentration of CCL17and CCL22in AR were significantly higherthan NAR and healthy volunteers, the difference was statistically significant(P<0.05).CCL17showed positive correlation with CCL22by linear correlationanalysis（r=0.565,p<0.05）.Conclusion: The increased expression of chemokine CCL17and CCL22in AR waswell evidenced and Play an important role in the pathogenesis of AR. And they arepositive correlation.