Analysis On Osteoporosis Status Among 1155 Women From Orthopedics In One Hospital Of Siping City

Objective:The study was aim to analyze the prevalence and influencing factors of osteoporosis(OP)among 1155 women from orthopedics in one hospital of Siping city. Multi factors Logistic regression analysis was used for analyzing the prevalence of OP in 280 postmenopausal women from 1155. And the risk factors and protective factors were found out to provide experimental basis for the prevention and treatment of OP.Methods:(1)Test lumbar bone mineral density of 1155 females who from orthopedics in one hospital of Siping city between March 2015 to March 2016 with GE dual-energy X-ray absorptiometry of American. Collect basic information of subjects and diagnose osteoporosis according to Word Health Organization( WHO)osteoporosis standards.(2)Test bone gla protein(BGP), calcitonin(CT), parathyroid hormone(PTH),25-(OH)D(VD), estradiol(E2) with Roche electrochemical luminescence analyzer of German and test the level of blood calcium(CA), blood phosphorus(P), alkaline phosphatase(ALP) in blood with German Roche automatic biochemical analyzer.(3)SAS 9.2 was used for statistical analysis, measurement data were compared by using two independent samples t test, count data using ?2 test analysis. Multi factors Logistic regression analysis was used to screen the independent risk factors and protective factors of OP.Results:The total prevalence of OP among 1155 subjects was 16.97%. The prevalence rate of OP in different age group were 0. 35%?5.40%?20.32%?44. 38%?60.98% respectively in 40 years old, 40 years old~, 50 years old~, 60 years old~ and 70 years old~. There was no significant difference in the prevalence of OP between different body mass index(BMI), degree of education and monthly income. The prevalence rate of OP in the non regular physical exercise group was higher than that in the physical exercise group(P<0.001). There was a high prevalence of OP in the population with a history of birth, and the more parity, the higher prevalence(P<0.001). The prevalence of OP in late menarche women was higher than that in early age(P<0.001). There were significant differences in the prevalence of OP among different menopausal status groups(P<0.001). The prevalence of OP in the non menopausal women, menopausal women and postmenopausal women were 1.65%, 17.69% and 42.50%, respectively.The results of single factor analysis of OP in postmenopausal women showed that age, physical exercise, menopausal years and 25-(OH) D content may be related to OP. The result of multi factors logistic regression analysis showed that 25-(OH) D was a risk factor for the prevalence of OP in postmenopausal women(P=0.003, OR=3.498, 95%CI:1.516-8.073). The risk of OP prevalence in postmenopausal women whose content of 25-(OH) D less than 36.00ng/ml in blood was 3.498 times compared with them whose 25-(OH) D concentration was higher than 36.00ng/ml in blood. Physical exercise was a protective factor for the prevalence of OP in postmenopausal women(P<0.001, OR=0.032, 95%CI:0.012-0.083), The prevalence of OP in postmenopausal women with regular exercise was significantly lower than that in non regular physical exercise.Conclusion:(1)The total prevalence of OP among 1155 subjects was 16.97%.(2)The prevalence rate of OP in females increased with age and parity. The incidence of OP was high in non regular physical exercise, late menarche and postmenopausal women.(3)lower concentrate of 25-(OH) D in blood was a risk factor for the prevalence of OP in postmenopausal women, and physical exercise was the protective factor of OP in postmenopausal women.