The Relevance Study Of Simultaneous Examination Of Spleen-asthenic Syndrome's Microcosmic Index And Its Symptoms

ObjectiveBased on the previous quantifiable diagnosis of spleen asthenic syndrome and microcosmic syndrome differentiation research,this thesis aims to discuss the relations between subjective and objective index of spleen asthenic syndrome,thus to promote the combination of macrocosmic and microcosmic syndrome differentiation,the microcosmic indexes of spleen asthenic syndrome("the vitality ratio of salivary alpha-amylase" and "xylose excretory rate")and diagnostic scores of splenic asthenia patients and total scores of the registration form of spleen asthenic syndrome revealed from diagnostic scores record will be underwent relevant analysis.Methods?Document Research:Collect the documents of previous study about the relations between the two indexes andspleenasthenic syndrome through consulting and analyzing.? Clinical and trial studies:a.The(data of this)case study comes from spleen and stomach disease outpatients and inpatients ofThe First Affiliated Hospital of Guangdong University of Traditional Chinese Medicine,who suffer from CSG,or in the view of traditional Chinese medicine,spleenasthenic syndrome.b.Make a registration form of the documents about the four diagnosis of spleen deficiency syndrome,scrupulously record the symptoms and physical signs of patients in the research and give quantitative scores to them according to diagnostic scores record of spleenasthenic syndrome.c.Collect samples of saliva and urine from those spleen asthenic patients who have been included in the study,and test SAA and xylose excretory rate according to certain procedures and methods.d.First,use IBM SPSS Statistics Version 19.0 to process and analyze the data collected from clinic and laboratory.Second,employ chi square test and ANOVA to compare gender and age differentiation in various groups.Third,undergo cluster analysis of the main symptoms of spleen asthenic syndrome,and then sort a group of data into several types based on its inherent regularity so that the result of data analysis will be more objective.Fourth,combine the total scores of spleen asthenic syndrome diagnosis and four diagnosis information as well as two microcosmic indexes so that degree of relevance can be shown through the changes of number among the variables.Fifth,undergo the analysis of multiple linear regression with the combination of the main symptoms of spleen asthenic syndrome and two microcosmic indexes to get the regression coefficient and linear regression equation and run through the significance test of relevant indexes by means of combining several independent variables to estimate independent variables.Results? Revealing from the results of cluster analysis:In the symptoms suggested from the registration form about four diagnosis information of spleen asthenia,the following eight symptoms of spleen asthenia patients can be concluded into one group as they share similar nature,namely,physical lassitude,loose stool,nausea,chilliness and cold limbs,anorexia,stomachache and abdominal distention.Meanwhile,the following four symptoms:belching,acid regurgitation,thirsty and bitter mouth,pains from both sides of the upper part of body fail to be grouped in the above classic symptoms of spleen asthenia,considering different manifested symptoms.They cannot be in the same group because of the inherent regularity.? Revealing from the results of relevant analysis:As the vitality ratio of sAA is in positive correlation with xylose excretion rate,there exists statistical difference.There is a positive correlation between the total scores of spleen asthenic syndrome diagnosis and the information about the four diagnosis,showing a statistical difference.No statistical significance is shown in the comparison of two microcosmic indexes and the total scores of spleen asthenic syndrome diagnosis,despite there' s linear relation between them.The two microcosmic indexes and the total scores of four diagnosis are in negative correlation and have statistical significance,indicating that there' s clinical significance in the assessment of patient' s condition through two classic microcosmic indexes.? Revealing from the results of Multiple Linear Regression:The vitality ratio of sAA in spleen asthenic syndrome patients has a close relation with the main symptoms of spleen asthenia(abdominal distention and physical lassitude).It is negatively correlated and the two symptoms contributes more to the vitality ratio of sAA,suggesting that with the decrease of sAA vitality ratio,spleen asthenic patients are more likely to have abdominal distention,physical lassitude and anorexia.Spleen asthenic patients' xylose excretion rate is in relatively close correlation with the main symptoms of spleen asthenic(belching,anorexia and continuing abdominal pain).They are in negative correlation indicating that spleen asthenic patients are more likely to have the symptoms of belching,aneroxia and continuing abdominal pain.Conclusions? Revealing from the results of cluster analysis:The following eight symptoms of spleen asthenic patients can be concluded into one group,namely,physical lassitude,loose stool,nausea,chilliness and cold limbs,anorexia,stomachache and abdominal distention.All of these are the signs of dysfunction of spleen and stomach and insufficiency of spleen yang.Meanwhile,the following four symptoms:belching,acid regurgitation,thirsty and bitter mouth,pains from both sides of the upper part of body fail to be grouped in the above,all of which are the signs of disharmony between liver and spleen.This gives us a hint that different excess and deficiency syndromes cannot be grouped into one.? Revealing from the results of relevant analysis:(1)Since the vitality ratio of sAA is in positive correlation with xylose excretion rate,it indicates that both the vitality ratio of sAA and xylose excretion rate have declination to various degrees in most of the spleen asthenic patients,which conforms to the previous study results and reflects that there's a certain internal relation between two microcosmic indexes of spleen asthenic patients.(2)There is a positive correlation between the total scores of spleen asthenic syndrome diagnosis and the information about the four diagnosis,showing that despite its advantage of higher accuracy,sensitivity,specificity in the diagnosis of spleen asthenic syndrome,its scores have referential significance to the assessment of patient' s condition.Meanwhile,it can be furthered concluded that the symptoms of spleen asthenia selected from the registration form are classic.(3)There is linear relation between the two microcosmic indexes and the total scores of spleen asthenic syndrome,but no statistical difference can be shown.(4)The two microcosmic indexes and the total scores of four diagnosis are in negative correlation and have statistical significance,which can be implied that the higher the patients' scores is,the more serious their spleen asthenia is,with the inclination of two microcosmic indexes.Moreover,to the spleen asthenia patients,the diagnostic significance and relevant relations of grade of these two microcosmic indexes can be further proven,which can also reveal patients' insufficient and weak condition of spleen.? Revealing from the results of Multiple Linear Regression:(1)The vitality ratio of sAA in spleen asthenic syndrome patients has a close relation with the main symptoms of spleen asthenic(abdominal distention,physical lassitude and anorexia),indicating that the changes of sAA vitality ratio are more likely to be reflected if the symptoms of abdominal distention and physical lassitude appear at the same time.In other words,the smaller is the sAA ratio,the easier spleen asthenic patients are likely to have abdominal distention,physical lassitude and losing appetite.(2)The xylose excretion rate of spleen asthenic patients is in close relation with major symptoms of spleen asthenia,namely,belching,anorexia and continuing abdominal pain.The fact that they are in negative correlation suggests the lower is xylose excretion rate,the easier are the spleen asthenic patients to have belching,anorexia and continuing abdominal pain.In the wide range of spleen asthenia,either low emergency capability caused by overexcited parasympathetic nerve or patient's low absorbing ability result in manifestation of spleen dysfunction.