Xinjiang Kazak Ethnic CETP Gene Poolymoorphism And Lipid And Hyperlipidemia Relatioonship Between TCM Syndroome Types In Xinjiang Kazak Ethnic CETP Gene Poolymoorphism And Lipid And Hyperlipidemia Relatioonship Between TCM Syndroome Type

Objective: Understand xinjiang kazak ethnic CETP gene A373 P,c.* 84 g > A mutation loci polymorphism and lipid levels and the relationship between TCM syndrome of hyperlipemia.Methoods: xinjiang urumqi surrounding areas as,deals with the method of random cluster sampling,of kazak residents in communities,villages and other samples.According to the epidemiological investigation method formulated questionnaire hyperlipemia.Blood detection of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C).Extraction of genomic DNA,using polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP)in 218 cases of xinjiang kazak hyperlipidemia patients and 230 healthy controls in the CETP for classification,and its lipid levels were detected.To the doctor of traditional Chinese medicine dialectical points of 218 patients with hyperlipidemia model,compare the genotypes and lipid levels and the relationship between TCM syndrome type.Results:Subjects to complete the test analysis(1)into the results of detection of cholesterol ester transfer protein 2 site three genotypes AA,AG,GG,with GG genotype frequency highest,xinjiang kazak nationality in hyperlipidemia group rs5880 loci(c.* 84 G > A)AA,AG and GG genotype frequency respectively 0 cases,11 cases and 206 cases of hyperlipidemia in the group A and G allele frequencies were 2.5%and 97.5% respectively,in the healthy control group A and G allele frequency of 3.7% and96.3%,respectively.(2)the xinjiang kazak ethnic CETP gene A373 P type hyperlipidemia group and healthy controls between serum TC,LDL-C.Rs1801706 loci hyperlipidemia in G allele carriers(AG,GG genotype)is the G allele carriers(AA genotype)had higher plasma TC and LDL-C level(P < 0.05);(3)rs1801706 sites GG genotype of phlegm turbidity deter a card with a maximum of 71 cases;Followed by liver and kidney Yin deficiency and spleen kidney Yang deficiency of the genotypes were 20.1% and15.3%.AG genotype of phlegm turbidity repression at most 16 cases.AA genotype all syndrome rarely,liver and kidney Yin deficiency in 2 cases,phlegm turbidity repression in1 case.GG,AA,further statistical analysis shows that the AG genotype differences exist in the form than,phlegm turbidity repression is higher than liver and kidney Yin deficiency,liver and kidney Yin deficiency is higher than the spleen kidney Yang deficiency,spleen and kidney Yang deficiency is higher than the qi and blood stasis,and qi stagnation and blood stasis is higher than the Yin hand.Coonclusioon: Xinjiang region turn gene A373 P lipoprotein,c.* 84 g > A polymorphism and may not be related to the level of hyperlipidemia A373 P genotype GG and hyperlipidemia phlegm and blood stasis resistance may be related to each other.