Clinical Research Of Unruptured Luteinized Syndrome Infertility Treated By Traditional Chinese Medicine

Objective:Luteinized unruptured follicle syndrome(LUFS)[1]has become one of the important reasons for the occurrence of infertility.Through the study of acupuncture and traditional Chinese medicine decoction orally and external application of Chinese medicine and Western medicine HCG intramuscular injection for treating luteinized unruptured follicle syndrome(LUFS)patients with infertility,analysis of the factors related to LUFS pathogenesis,clinical curative effect are compared between the four groups of treatment,add a new effective,safe and convenient way for prevention and treatment LUFS exploration.Methods:In 200,the choice conformed to the diagnosis standard of LUFS patients with infertility cases,follicular phase according to different conditions of patients,oral decoction,CC,LE,foliiculi bromocriptine,dexamethasone,intramuscular injection of HMG pretreatment on ultrasound in monitoring follicle diameter was greater than or equal to 18mm,were randomly divided into four groups:treatment.Group A(oral medicine decoction group)45 cases,a total of 177 menstrual cycles;group B(acupuncture group)32 cases,a total of 162 menstrual cycles;group C(traditional Chinese medicine treatment group)47 cases,a total of 150 menstrual cycles;D group(Western medicine group HCG)76 cases,a total of 211 months cycle;analysis of factors related to the pathogenesis of LUFS,the four groups after the treatment of ovulation,LUFS recurrence,clinical pregnancy outcomeResults:(1)comparison of four groups:ovulation group A a total of 177 observation cycle,65 cycles of ovulation,ovulation rate was 36.72%;B group had 162 observation cycle,106 cycles of ovulation,ovulation rate was 65.43%;C group had 150 observation cycle,67 cycles of ovulation,ovulation rate was 44.66%;D group a total of 211 observation cycle,124 cycles of ovulation,ovulation rate was 58.76%.B group compared with A group,C group,there was significant difference(P<0.05),D group and A group,C group,there was significant difference(P<0.05),A group and C group,B group and D group,there was no statistical significance(P>0.05).(2)between the four groups:A group LUFS recurrenced 177 observation period,the recurrence of LUFS 26 cycles,the recurrence rate of LUFS was 14.69%;group B total of 162 observation period,the recurrence of LUFS 21 cycles,the recurrence rate of LUFS was 12.96%;group C total of 150 observation period,the recurrence of LUFS 24 cycles.The recurrence rate of LUFS was 16%;group D total of 211 observation period,the recurrence of LUFS 54 cycles,the recurrence rate of LUFS was 25.59%.A group,B group,C group were compared with the D group,with significant statistical difference(P<0.05);there was no significant difference between the two groups(P>0.05).(3)Ovulation induction for 7 days,according to statistics,four groups of serum progesterone value:A group E2:330.41 ±200.48pg/mL,P:15.34± 6.04ng/mL;B group E2:490.46 ± 381.88pg/mL,P:22.07 ±14.35 C E2:334.55± 190.35 ng/mL;group pg/mL,P:17.64 ± 7.95ng/mL;group D E2:462.39±291.35 pg/mL,P:24.79 ± 13.61ng/mL.B group and D group were compared with A group and C group(P<0.05),but there was no significant difference between A group and Cgroup,B group and D group(P>0.05).(4)comparison of pregnancy outcomes between the two groups:A group of clinical pregnancy in 19 cases;B group of clinical pregnancy in 15 cases;C group of clinical pregnancy in 20 cases(42.55%);D group of clinical pregnancy in 23 cases(30.26%).A group,B group,C group,the clinical pregnancy rate were compared with the D group,there was statistical difference(P<0.05),the clinical pregnancy rate among the other groups were not statistically significant(P>0.05).(5)the incidence of LUFS related factors:from the analysis of occupation and education level,the incidence of patients with mental labor(87.01%)was significantly higher than that of manual workers(12.99%).In the education level,the university culture was accounted for 85.50%,the high school culture wasaccounted for 10%,the junior middle school culture occupied the 4.50%,visible education level was higher,the incidence rate was higher.From the analysis of related disease history,the hypothalamic pituitary ovarian axis of reproductive endocrine disorders(54.15%),of which the majority of polycystic ovary syndrome(PCOS)accounted for 35.34%;followed by pelvic factors(37.44%),which accounted for 24.74%of endometriosis(EMS).According to the analysis of the psychological factors,30.50%of the patients with mental disorders were LUFS,and those with depression accounted for more than 30%,while those with irritability accounted for about 21%.(6)Comparison of four groups of PCOS,PID,EMS,LUFS:PCOS patients caused by infertility infertility patients,B group and D group respectively with ovulation rate compared with A group,C group,there was significant difference(P<0.05),A group and C group,B group and D group,there was no statistical significance(P>0.05);A group,C group,B group,clinical pregnancy rate were compared with the D group,the difference was statistically significant(P<0.05);no significant difference among other groups(P>0.05).In PID infertile patients,the ovulation rate of C group was significantly different from that of group A,group B and group D(P<0.05).The clinical pregnancy rate in group C and group B was significantly different from that in group A and group D(P<0.05).In EMS infertile patients,the ovulation rate of C group was significantly different from that of group A,group B and group D(P<0.05).The clinical pregnancy rate in group A and group C was significantly different from that in group B and group D(P<0.05).Conclusion:Decoction of Chinese medicine,acupuncture and external application of traditional Chinese medicine in three kinds of Chinese medicine for treatment of luteinized unruptured follicle syndrome caused by infertility,can improve the cycle ovulation rate and clinical pregnancy rate(40-60%)(42-46%),reduce the incidence of LUFS;the use of Chinese medicine treatment highlights the characteristics and advantages of safety and effectiveness simple,has certain clinical application value.Conclusion:Decoction of Chinese medicine,acupuncture and external application of traditional Chinese medicine in three kinds of Chinese medicine for treatment of luteinized unruptured follicle syndrome caused by infertility,can improve the cycle ovulation rate and clinical pregnancy rate(40-60%)(42-46%),reduce the incidence of LUFS;the use of Chinese medicine treatment highlights the characteristics and advantages of safety and effectiveness simple,has certain clinical application value.