Study On The Relationship Between Homocysteine,Osteoporosis And Coronary Heart Disease In Elderly Patients

BackgroundCoronary heart disease is a cardiovascular disease,whose morbidity and mortality are high,pathogeny is complex,pathogenesis has not been announced so far,influence on human physical and mental health is serious,prevention and treatment is a hard work.There were some researches about the relationship among homocysteine,osteoporosis and coronary heart disease,but evidence based evidence about the relationship among homocysteine,osteoporosis and angina pectoris in elderly patients is still scarce.ObjectiveTo analyze the relationship between the occurrence and severity of angina pectoris in elderly patients,provide a rationale for the prevention and treatment of angina pectoris in elderly patients.MethodSeventy elderly patients with angina pectoris diagnosed by coronary angiography and seventy elderly patients without coronary heart disease,who were admitted to the People's Hospital of Zhengzhou from January 2015 to December 2016,were assigned to the case group and the control group,respectively.Those subjects enrolled were recorded in Excel regarding gender,age,past history(alcohol drinking,smoking,hypertension,diabetes),homocysteine(assayed by S-adenosine hydrolase),calcaneus bone mineral density(assayed by ultrasonic bone densitometry made in Korea),and severity of angina pectoris(reflected by Canadian Cardiovascular Society's classification and Gensini score)and so on.With the help of SPSS20.0,factors affecting the occurrence of angina pectoris in elderly patients were analyzed by the X~2 test and the multiple Cox model,and the relationship among homocysteine,osteoporosis and the severity of angina pectoris in elderly patients were analyzed by spearman rank correlation analysis.The difference was statistically significant when P<0.05.Result(1) X~2 test showed that history of smoking and alcohol drinking,hypertension,diabetes,hyperhomocystinemia and osteoporosis were suspicious factors affecting the occurrence of angina pectoris in elderly patients(P<0.05).(2) Multiple Coxmodel showed that hypertension(?=0.529,OR=1.269),hyperhomocystinemia(?=2.426,OR=2.983)and osteoporosis(?=1.433,OR=2.015)were independent influencing factors affecting the occurrence of angina pectoris in elderly patients(P<0.05).(3) Spearman rank correlation analysis showed that homocysteine was positively correlated with CCS score and Gensini score(rs=0.624?0.807,P<0.05),that calcaneus bone mineral density was negatively correlated with CCS score and Gensini total score(rs=-0.583 ?-0.727,P<0.05),and that serum homocysteine was negatively correlated with calcaneus bone mineral density(rs=-0.753,P<0.05),in case group.Serum homocysteine has nothing to do with calcaneus bone mineral density in control group(P>0.05).ConclusionHyperhomocystinemia and osteoporosis are independent influencing factors affecting the occurrence of angina pectoris in elderly patients,serum homocysteine and calcaneus bone mineral density,which is negatively correlated,have a closely relation with the severity of angina pectoris in elderly patients.