Study On The Relationships Between The Syndromes Of Traditional Chinese Medicine And Relative Factors Of Peptic Ulcer Bleeding

Objective: Peptic ulcer bleeding(PUB)is the main reason of upper gastrointestinal bleeding,and one the common clinical Digestive System Department disease.This study mean to find out the corresponding relationship between the traditional Chinese medicine(TCM)syndrome types and relative clinical factors,to grasp its epidemiological characteristics in recent years,and try to provide a certain reference value for Disease-based TCM.Methods: Using the clinical epidemiological method,the data of patients with PUB all from the first affiliated hospital of guangxi university of traditional Chinese medicine from October 2015 to October 2017,including general information of the patient,gastroscope results,and the four diagnostic information.We developed clinical data observation table,sorted out the characteristics of various variable,and all the data were analyzed Statistically to find out the relationship between the characteristics of TCM syndrome distribution and clinical factors.Results: 1.This study analyzed by frequency statistics,factor analysis and clustering analysis of the four diagnostic information of 243 cases with PUB,it was preliminarily found that the main position of the disease is liver,spleen and stomach,and the deficiency,heat,depression and dampness heat was the main pathogenesis.The classification of TCM syndrome mainly included 41 cases of stomach heat intrinsic syndrome(16.87%),34 cases ofliver-fire infringed stomach syndrome(13.99%),38 cases of spleen deficiency with dampness heat syndrome(15.64%),98 cases of spleen-stomach weakness syndrome(40.33%),32 cases of deficiency-cold of spleen and stomach syndrome(13.17%).There was a significant difference between syndrome types(P<0.05),Syndrome types of spleen-stomach weakness syndrome were significantly more than other syndromes(P<0.05).2.The gender of PUB patients were significant more than male,while the age of onset were young people.And there was a statistical difference in gender and age in the distribution of TCM syndromes(P<0.05).Among them,liver-fire infringed stomach syndrome was more common in female,and the stomach heat intrinsic syndrome was more common in male(P<0.05).The incidence of stomach heat intrinsic syndrome was significantly higher in young and middle-aged patients than that in elderly patients,while the elderly patients had more spleen-stomach weakness syndrome than those in young and middle-aged patients(P<0.05).3.The infection rate of helicobacter pylori(HP)in PUB patients was63.37%,with the highest infection rate in liver-fire infringed stomach syndrome,followed by stomach heat intrinsic syndrome and spleen deficiency with dampness heat syndrome.But HP infection in all the syndrome types have no obvious difference by statistical analysis(P>0.05).4.The common adverse life factors of PUB patients include addicted to smoking,addicted to alcohol,eating disorders,drug treatment,overwork and unpleasant feelings.The people who addicted to alcohol has the highest rates of stomach heat intrinsic syndrome and spleen deficiency with dampness heat syndrome,unpleasant feelings has the highest rates of liver-fire infringed stomach syndrome(P<0.05).5.Occupational category in all the syndrome types have statisticallydifference by statistical analysis,and the onset concentrated was in professionals(P>0.05).6.Endoscopic performance of PUB patients:the bleeding duodenal ulcer is the most common clinical symptom,followed by bleeding gastric ulcer,but the location of all the syndrome types was no statistically significant mean.The single ulcer are more in the liver-fire infringed stomach syndrome(P<0.05),but the other TCM syndrome types was not affected by the number of ulcers.Under the endoscopy,bile reverse flow are more in the liver-fire infringed stomach syndrome,gastric mucosal atrophy type are more in the spleen-stomach weakness syndrome(P<0.05).7.Initial symptoms of all the syndrome types was no statistically significant mean(P>0.05).PUB bleeding degree of comparative:the degree of comparative in spleen-stomach weakness syndrome are serious than stomach heat intrinsic syndrome,liver-fire infringed stomach syndrome and spleen deficiency with dampness heat syndrome.And the degree of deficiency-cold of spleen and stomach syndrome are serious than stomach heat intrinsic syndrome(P<0.05).There was no significant difference in the severity of bleeding among the remaining syndrome types(P>0.05).Conclusion: The results of this study showed that the TCM syndromes of PUB are mainly related to deficiency of spleen,heat accumulation in the stomach,liver-fire infringed stomach,spleen deficiency with dampness heat and deficiency-cold of spleen and stomach.We could conclude that spleen-stomach weakness syndrome was dominant in PUB of TCM syndrome types,and the pathogenesis of this disease is mainly "spleen deficiency".There are pathogenic factors and disease-bit elements.Pathogenic factors include dampness,heat,qi stagnation,qi deficiency and yang deficiency.It provides the basis for the clinical treatment for PUB patients notice tonifying qi,andappropriate treatment with heat-clearing,damp-excreting and relieving qi stagnancy in Liver.We can individualized to guide patients to give up smoking and drinking,avoid improper diet,gloomy mood,over exertion and other factors to prevent the disease.