Theraputic Effect Of Dapoxetine In The Treatment Of Chronic Prostatitis Combined With Premature Ejaculation:A Randomaized Controlled Study

ObjectivesTo evaluate the therapeutic effect and safety of dapoxetine in the treatment of acquired premature ejaculation(PE)combined with chronic prostatitis(CP).MethodsA number of 190 eligible patients since October 2015 to December 2016 which was chosen from Urology outpatients in Qilu Hospital of Shandong University,Qilu Hospital of Shandong University(Qingdao),Affiliated Reproductive Hospital of Shandong University,Liaocheng People’s Hospital and the Second Hospital of Shandong University was divided randomly into experimental group(n=95)and control group(n=95).Dapoxetine was administered orally at 30mg and 2 hours before sexual behavior in the experimental group.Both groups received conventional medical and behavior therapy.The medical therapy included tamsulosin(0.2mg,orally,qn)and antibiotics.The Premature Ejaculation Diagnostic Tool(PEDT)and the National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI)were performed before and 2/4 weeks after treatment to evaluate the symptoms and treatment outcomes.Statistical method was applied to process the data.Quantitative data was performed as x±s.One-way Anova is applied to analyze the variety inside one group due to treatment time.Two-way Anova is applied to analyze the variety between two groups.Pearson analysis is applied to analyze the correlation between two groups.P<0.05 is defined with a statistical significance.ResultsFollow-ups was accomplished in 85 and 83 in the experimental group and control group.No statistical significance(P>0.05)was found between the two groups in age,weight,height,5-item version of the International Index of Erectile Function(IIEF-5)score.After 2 weeks treatment,the NIH-CPSI scores in both groups improved significantly(P,<0.001,Pc=0.037),the PEDT scores only improved significantly in experimental groups(P<0.001).After 4 weeks treatment,both scores in both groups improved significantly(P<0.001).The PEDT scores in experimental group improved more significantly compared to control group(P<0.001)while the NIH-CPSI scores had no significantly meaning Between groups(P=0.237).Moreover,the life quality scores of the NIH-CPSI in experimental group improved more significantly compared to control group(P<0.01).The variation of NIH-CPSI was positively correlated with that of PEDT in experimental group.(r=0.245,P=0.025).No severe adverse reaction is observed during the clinical experiment.Conclusions1.Traditional therapy has curative effect on PE and CP symptoms in CP patients with acquired PE,while dapoxetine combined therapy are much more effective and rapidly than the traditional therapy.2.Dapoxetine not only has curative effect on PE symotoms but also improves the life quality in CP patients with acquired PE.3.No severe adverse effect is observed in CP patients with acquired PE who go through dapoxetine therapy.