The Expression And Biological Function Of Inducible Co-stimulatory Molecule In Exercise

As the newest family member of the CD28 , the inducible co-stimulator (ICOS ) combined with its ligand GL50 plays a very important role in the regulating immune responses of the body. The results of the finished research work in the recent years have showed that the inducible expression of ICOS on the surface of the activated T cells was closed related to the many biological functions including the inflammatory reactions, the development of auto-immune diseases, and the regulating immune response. As a result the potential applications of ICOS has drawn extensive attention and interesting of people. However, up till now a great deal of research work on the biological functions of ICOS mostly limited to and focus on mice or immune diseases of clinical settings, and to the author's knowledge there is still not a publisher on the ICOS function in sport immunology or in the athletes with entense exercises training regularly. Furthermore, the research on the effects of chronic suppression on the immune functions of athletes with prolonged exercise training has always been a hot topic and rise a great interesting of a lot of researchers. This study is then designed to research the effects of physical training on immunization of athletes by the means of observing the ICOS expression on T cells in the peripheral blood cell in vitro as well as characteristics of ICOS expression and its functions in vivo.PurposesThe purposes of this study is designed to investigate such phenomena as follows:1. To investigate the characteristics and biological functions of ICOS expression as well as its inherent relationships to such factors as stress response and T-cell activation at cell level by means of incubation of T-cells of healthy adults peripheral blood cells in vitro.2. To identify the inherent relationships among stress response, T-cell activation and ICOS expression by means of observe and study the characteristics of ICOS expressions on T-cells in peripheral blood cells from the athletes who were in persistent...