Expression And Clinical Significance Of PTTG, BFGF And C-myc In Cervical Cancer

ObjectiveTo investigate the expressions and clinical significance of pituitary tumor transforming gene (PTTG) in cervical cancers, meanwhile identify their relationships with basic fibroblast growth factor (bFGF) and c-myc proteins.Methods60 cases of cervical cancer were collected from Affiliate Hospital of Medical College and Hiserve Hospital of Qingdao, which were diagnosed by operation or biopsy ,none of them had been treated by chemotherapy, radiotherapy or biotherapy before. 30 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of normal tissue were choosed as control.Expressions of PTTG, bFGF and c-myc were detected by immunohisto-chemistry SP method. The results were statistically analyzed by SPSS 11.5.Results1 .The positive expression rates of PTTG was significantly higher in cancer tissues(56. 67%) than in CIN and normal tissues (χ~2=14.244; P<0.01).2. The relationship between the expression of PTTG and the clinical- pathologic staging: The expression of PTTG was higher in FIGO stages ofⅢ,Ⅳthan the stages ofⅠ,Ⅱ(χ~2=10.809; P<0.01), was also higher in pathologic grading G3 than G2/G1 (χ~2=6.787; P<0.01) ,and lymphnode metastasis (P= 0.014). The expression of PTTG was not related to the age and pathologic type (χ~2=0.045; P>0.05) .3.Expressions of bFGF and c-myc proteins were positively correlated with that of PTTG (τ=0.287, 0.190; P<0. 01).Conclusion1 .Increased PTTG may play an important role in the carcinogenesis of cervical cancers.2.And it was closely related to the clinical staging, pathologic grading and lymphnode metastasis of the tumor.3.All these effects are probalbly induced through promoting the expression of bFGF and c-myc proteins.