Immunohistochemistry Study And Clinical Implication Of Survivin Gene In Laryngeal Squamous Carcinoma

The production of carcinoma is because the alteration of kinds of gene which control cell growth and apoptosis,which induce cell transformation and continous proliferation variation of kinds of gene include oncogene activation , anti-oncogene inactivation and apoptosis anomalism.Cell multiplication and apoptosis disquilibrium may lead to the occurrence of oncogenic, and influent biological behaviour of oncogene derectly.Survivin is the fortis anti-apoptosis gene.The core mechanism is to activate Caspase and dissolve protein cascadely, Survivin may effect Caspase derectely by adhering to the activated Caspase -3 , -7, blockade apoptosis procedure,inhibite cell apoptosis. Survivin expression depends on cell life cycle,and it is only expressed on G2/M.Study confirmed: Survivin promoter include 4 G1 copy of repression. survivin promoter is typically activated in M stage,which demonstrates Survivin is a cell life regulation gene , Survivin ioverexpression acceletates cell transformation to S stage,hold back G1 stage,romote cell multiplication. Survivin is expressed in transformant cell strain and almost all malignant tumour of human,including melanoma,nerve fibroblast, breast cancer, bronchogenic carcinoma, digestive system genital system hematological system To detect the expression of Survivin, a novel inhibitor of apoptosis,in laryngeal carcinoma and investigate the relation between the expression of Survivin and pathological features of laryngeal carcinoma and to provide a theoretic basis of for laryngeal carcinoma in etiology, early diagnosis and prognosis...