The Influence Of Organism Injury Caused By Chemotherapy And Bone Marrow Transplantation On The Angiogenesis And Tumor Growth Of The Lewis Lung Carcinoma

Background and ObjectivesThe blood supply is the most important prerequisite condition during the processof tumor growth. The tumor angiogenesis depends on the proliferation and migration of vascular endothelial cells. In the past, we considered that tumor angiogenesis is because of proliferation and metastasis of differentiated, precursor vascular endothelial cells arising from the existing blood vessels. But, the recent research discovered that bone marrow stem cell also participates in the tumor angiogenesis. The stem cells when stimulated by specific factors(G-CSF , GM-CSF , thrombospondin and so on) can differentiate to vascular endothelial progenitor cells. When these endothelial progenitor cells are acted upon by other factors, they can enter the peripheral blood circulation, and differentiate into the vascular endothelial cell at the site of the physiological and the pathological angiogenesis. In the light of this new research, we now consider that the process of the tumor angiogenesis includes the proliferation, migration of the region vascular endothelial cells and the differentiation, participation of the blood vessel endothelium precursor cells.In clinical practice, during the rest period of MTD chemotherapy, both erythropoietin and granulocyte colony-stimulating factor (G-CSF) are often used for the patients to help them in recovery from myelosuppression, which are induced by MTD chemotherapy regimens. But in some trials, patients using recombinant erythropoietin and G-CSF after MTD chemotherapy were associated with a worse outcome. This maybe explained by the fact, that they may promote the mobilization...