Analysis Of IL-1β, IL-8, TNF-α, PGE₂ In Expressed Prostate Secretion Of Chronic Prostatitis

Objective To investigate the levels of interleukin-1β(IL-1β),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),prostaglandin E₂(PGE₂) in expressedprostate secretion(EPS) of chronic prostatitis(CP) patients and to evaluate thesignificance to the type, pathogenesis and diagnosis of CP.Methods IL-1β,IL-8,TNF-α,PGE₂ levels were measured in EPS of 100 CPpatients and 20 normal controls by radioimmunoassay. Urine and EPS were culturedaccording to Meares-Stamey methods. NIH-CPSI(NIH-Chronic prostatitis symptomindex)was performed by every patient.100 CP patients were divided into 3 types:â…¡(n=11),â…¢a(n=66)â…¢b(n=23).Results The levels of IL-1β,IL-8,TNF-α,PGE2 in typeâ…¡group were higherthan typeâ…¢a,â…¢b and control group(p＜0.01), in typeâ…¢a group was higher than intypeâ…¢b group and control group(p＜0.01). There was no statistically significantdifference between typeâ…¢b group and control group(p＞0.05). There was a positivecorrelation between the levels of IL-1βand TNF-α, PGE₂(r=0.563,r=0.826,p＜0.05).There was also a positive correlation between WBC count in EPS and IL-8level(r=0.547, p＜0.01).The levels of IL-1βand PGE₂ were highly related to the scoreof pain severity and/or discomfort with NIH-CPSI (r=0.506,p＜0.01).But nocorrelation was found between NIH-CPSI and the levels of IL-1β,IL-8,TNF-α,PGE₂.Conclusions The levels of IL-1β,IL-8,TNF-α,PGE₂ are elevated in EPS of typeâ…¡,â…¢a group, and maybe mediators of inflammatory in prostate. The results indicatethat IL-1β,IL-8,TNF-α,PGE₂ can serve as valuable makers for the diagnosis,typeand therapy of CP.