| Objective:Investigate relations of intramuscular injection meperidine hydrochloride solution and gluteus contracture disease. It was by manifold cause creative gluteus cum fasciae fibre contracture denaturalization,result in coxae function restriction, appear to be of proper gait, sign, coxae disfunction, especially coxae adduction difficulty and coxae abduction monstrous clinic syndrome that gluteus contracture disease gluteal muscle contracture, GMC again weigh fibrosis of gluteal muscle,gluteus contracture disease. Clinically with injection gender gluteus contracture disease most for much saw. The medicament much for with benzyl alcohol for solvent penicillin, in recent years in company with versus benzy alcohol solvent versus GMC influencing epidemiological survey discover, clinically hexy these go to ostracism know clearly benzyl alcohol solven, children GMC attack quantity scale-down, therefor adult GMC attack quantity gradually manifold to of the even much higher to childhood, injection meperidine hydrochloride with intramuscular injection meperidine hydrochloride sufferer rose most for promptitude, furthermore much automatic thickness gauge manhood queen. The objective of this experiment is to study the impact of intramuscular meperidine for the GMC. GMC pethidine injection after observing the cease recovery. The three components of the experiment, rats were intramuscular penicillin benzyl alcohol solution as a positive control group. Meperidine as the experimental group and the saline solution penicillin solution as a negative control group. Gait changes observed in rats, measuring the length and stretch muscle Zhang original length ratio, and pathological changes observed specimen. Intramuscular meperidine clear solution and the GMC, the GMC lead for clinical reference meperidine.Methods: 180-220 g body weight of 80 Wistar rats were randomly divided into 3 groups: one large group as a positive control group of 20, penicillin injection of benzyl alcohol solution, divided into 110 groups, 120 groups and 130 groups 1.4 Section 4 groups were injected in two weeks, four weeks, six weeks, eight weeks after the death of 2 large group of 20 negative control group. penicillin injection of saline solution into 210 groups, 2.2, 2.3 Section 2.4 Section 4 team Injection in two weeks, four weeks, six weeks, eight weeks after the death of 3 experimental groups in 40. 3.1a group which consists of eight groups stipulate Section 3.3a Section 3.4a group for two weeks, four weeks, 6 weeks, 8 weeks after the death; 3.1b pethidine injection group parentheses group nearest group 3.4b group during two weeks, four weeks, six weeks, eight weeks after the injection of pethidine injection, 2 weeks later executed. To avoid the pain caused by the injection gait change observations, All rats in the 2 hours after each injection End observed gait changes, and for the record. The rats were sacrificed after admission buttock muscle injection for the whole muscle color, flexibility, muscle tone, Zhang stretch fiber length measurement admission, the original band with a long, calculated ratios, After the test specimens were fixed with formalin fixative for the production of tissues After changes in muscle were observed under light microscope. All data were analyzed by SPSS.Results: 1 Gait observe:benzyl alcohol penicillin group gait in rats injected some three weeks after walking gait abnormalities claudication, After six weeks, all the rats were running a limp, eight weeks after rats claudication is very serious; saline group in the first seven weeks of penicillin when a rat is abnormal gait, walking slightly lame, During the rest of the rat found abnormal gait; 4 weeks after injection of the experimental group emerged a few rats running claudication. After six weeks, rats most unusual gait, can return to normal after they stop the injection. After 8 weeks significantly more rats abnormal gait, abnormal gait stop no significant recovery after injection.2 Muscle wait sheet pull spin and ortho length ratio tatistical analysis: benzyl alcohol group of four penicillin group were statistically significant difference between the two groups; NS Group 4 penicillin group no statistically significant difference between the two groups; 3.4a group and the experimental group with no significant difference between 3.4a, 3.1a group 3.1b group, Section 3.2a, 3.2b group, no statistically significant difference between the two groups was monitored.3 Gross specimen observe: 1.1 specimen observation group, the second largest group, 3.1a group 3.1b group, ruddy color shown muscle group can be seen, with no contracture, good muscle flexibility in 1.2 group stipulate group gluteal muscle monitored rats shows little pale and weakened flexibility, a few fibers found contracture constrictions. Section 1.3, Section 1.4, 3.3a Section 3.4a group 3.4b rats shows some gluteal muscle fiber contraction constrictions of 1-2 mm, 16.4 gluteus maximus layer of pale color, inflexible, the tendon tissue was seriously accompanied by the entire gluteal muscle contracture, synovial fluid increased.4 Light microscope observation: 2.1 light microscopy, Section 2.2, Section 2.3, Section 3.1a, 3.1b group, Group neat muscle fibers shown that nuclear size, color uniform chromatin ;1.1 Section 240 groups, Section 3.2a, 3.3b group slightly swollen body gluteal muscle cells, chromatin coloring moderate, the gap widened muscle fibers. Neutrophils and lymphocytes can be seen in 1.2Section , 3.3a Section, 3.4a group and 3.4b group shows muscle fiber disorder, was stained more lightly, nuclear condensation, significantly widened the gap between the muscle fibers. Neutrophil and lymphocyte infiltration between the muscle fibers and collagen fibers can be seen between the band; Section 1.4 curly fibers disorder, muscle cells shrink, and extended nucleus increased muscle fibers were arranged beaded, Gap muscle fibers increased significantly more neutrophils and lymphocytes, a lot of collagen fibers hyperplasia, Regional shows fibrosis large dense connective tissue collagen fibers. Seen in some coarse collagen fibers slender spindle cells, and collagen fibers in parallel to the same tendon structure similar.Conclusion : 1 Gluteal muscle in rats injected with penicillin could lead to rat GMC benzyl alcohol. GMC injection in January after most of the rats had symptoms six weeks after injection GMC syptoms. GMC very serious symptoms after 8 weeks, 2 Rats gluteal injection solution could lead to rat GMC meperidine. Most of the rats had six weeks after injection GMC symptoms after eight weeks of very few serious symptoms in rats GMC; 3 Gluteal muscle in rats 6 weeks after the injection of pethidine injection, the rats gluteal muscle can return to normal. Eight weeks after injection of pethidine gluteal muscle in rats, rats gluteal muscle could not be restored. 4 Frequent intramuscular penicillin saline solution is a significant factor GMC. 5 Adult rats gluteal injection of benzyl alcohol solution to the rat GMC outweighed the effect of penicillin meperidine solution.
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