Yiqi Yangyin Huoxue Principle Treats Precancerous Lesions Of Gastric Carcinoma Clinical And Experimental Study

Objective:Observes WEILING N0.1 to PLGC patient's clinical curative effect,and discusses Yiqi Yangyin Huoxue principle to PLGC the big mouse VEGF influence.Method:1 Clinical research:Divides into two groups stochastically 44 example PLGC patient(Qixu Yinxu Xueyu).The treatment group 23 examples, give WEILING NO.1 powder oral administration,the control group 21 examples,give WEIFUCHUN piece of oral administration.The treatment course is 6 months around,observes two group of patients to treat the symptom integral,the pathology integral and the curative effect improvement situation. 2 Experimental research:75 Wistar rats were randomly divided into model group,normal control group,low dose group,high dose group and WEIFUCHUN group of 15.The rat model of precancerous lesions of gastric carcinoma(PLGC) was established by four pathogenic factors in which MNNG was mainly used.Weimeisu was given 1.0g/kg per day in weimeisu group;Yiqi Yangyin Huoxue Recipe of 1.0g/ml,2.0g/ml drug concentration were given 10ml/kg per day in low dose group and high dose group.After 16 weeks observes the big mouse stomach mucous membrane pathological change, as well as Yiqi Yangyin Huoxue principle to VEGF level influence.Result:1 The clinical treatment result showed front that,after the treatment group cures the symptom integral,the pathology integral has the obvious difference(P<0.05),compares with the control group,has the obvious difference(P<0.05).2 The experimental study result showed that,the model group VEGF expression level and the normal control group quite obvious markup,the Chinese native medicine low,the high monitoring team and the model group compare the VEGF expression to decline,each group of differences have statistics significance(P<0.05).Conclusion:Yiqi Yangyin Huoxue principle treats this sickness to have the good clinical curative effect,can reverse PLGC the pathological state,and may improve the PLGC big mouse stomach mucous membrane pathology condition,declines the VEGF level.Thus the suppression endothelial cell growth and the blood vessel production,plays in front of the preventing and controlling PLGC role.