HuR And Survivin Are Overexpressed And Positively Correlated In Laryngeal Cancer

Objectives: To explore the correlation between HuR gene and survivin gene in laryngeal squamous cell carcinoma by analyzing their gene expression levels and their relationship with clinicopathologic parameters. Methods: The expression of HuR gene and survivin gene in 42 laryngeal carcinoma tissues from patients and 36 negative surgical margin tissue samples were detected by immunohistochemistry, respectively. The correlation of their expression levels and patients'clinical parameters were then analyzed by Pearson correlation analysis. Results:The expression of HuR and survivin in laryngeal cancer tissue were significantly higher than noncancerous laryngeal tissue(P<0.05),and their expression were positively correlated ,which was also statistically significant(P=0.7055, r=0.526). Both of their expression was correlated with T stage(P<0.05). Furthermore the expression of HuR was correlated with pathological grade(P<0.05). The overall survival rate of patients was 26.2%, and disease-free survival (DFS) was 21.4%. DFS in HuR negative-expression group was 46.2%, and 10.3% in HuR positive-expression group. The negative expression of HuR was associated with a longer mean patient DFS time (37.837±2.595), whereas positive expression of HuR was associated with a shorter mean DSF time (28.678±1.627 months).Conclusion:Both HuR and survivin were overexpressed in laryngeal cancer tissue.And their expression were positively correlated. The 3 years survival rate was correlated with T stage in laryngeal cancer with HuR or survivin positive expression. It indicated that HuR could regulate the expression of survivin.Through this way,it played an important role in transformation and progression of laryngeal cancer.