Radish Seed Water-soluble Alkaloids Mechanism Of Antihypertensive Effect In Spontaneously Hypertensive Rats

Objective: To explore the effects of the soluble Semen Raphani alkaloids on spontaneous hypertensive rats (SHR), plasm angiotension- II (Ang II) content and plasm renin activity (PRA). Method: Forty SHRs were randomly divided into five groups: untreated control group, the high, middle, low dosage group of the Semen Raphani soluble alkaloids, and irbesartan group, with eight rats in each group. SBP were measured respectively by tail-cuff technique before therapy and two weeks, four weeks, six weeks, eight weeks after therapy, plasm angiotension- II content and renin activity were measured after eight weeks therapy. Result: Eight weeks treatment later, the soluble alkaloids of Semen Raphani significantly declined the blood pressure of rats. Compared with that of irbesartan, the hypotensive function of high and middle dosage groups had no significant difference. Meanwhile, Semen Raphani decreased their plasm Ang II content greatly, while irbesartan increased plasm Ang II. But all of groups had no effect on their PRA. Conclusion: The hypotensive function of the Semen Raphani may be related to decreasing of plasm angiotension- II, but not to PRA or AT1R.