The Study Of The COX-2Expression In The HP Infected And Noninfected Gastric Ulcer And Gastric Cancer

objective:The purpose of the article was to study the COX-2expression in the HP infected and noninfected gastric ulcer(intestinal metaplasia, dysplasia) and gastric cancer, and the relationship between COX-2expression and gastric cancer and gastric ulcer, Providing an important basis for clinical diagnosis and treatment.Methods:immunohistochemical methods was used to exam gastric mucosal COX-2protein expression in patients with endoscopically and histologically gastric ulcer (pathological typing:intestinal metaplasia, dysplasia)、gastric cancer, and normal gastric mucosa. COX-2protein expression differences were analysized based on histopathological classifications and whether HP infected. Results:The study demonstrated that, in the gastric ulcer(intestinal metaplasia, dysplasia) and carcinoma, COX-2protein was expressed in inflammatory cells, glandular epithelial cells, cancer cells and a very small amount of normal mucosa epithelial cell. COX-2is usually not expressed in normal gastric mucosa. In the gastric ulcer(intestinal metaplasia, dysplasia) and gastric cancer group, the positive expression of COX-2was higher than in normal gastric mucosa group.gastric mucosa COX-2expression differences between groups,and COX-2expression of gastric mucosa between the HP positive groups,COX-2expression of gastric mucosa between the HP negative groups also.From normal gastric mucosa,gastric ulcer(intestinal metaplasia, dysplasia) to gastric cancer, the positive expression of COX-2was gradually increasing (P0.05).the positive expression of COX-2was higher in dysplasia group than in intestinal metaplasia group (P<0.05).In gastric cancer group, the positive expression of COX-2was higher than in the gastric ulcer group (intestinal metaplasia+dysplasia)(P<0.05). In HP positive gastric cancer group, the positive expression of COX-2was higher than in HP positive gastric ulcer group (intestinal metaplasia+dysplasia)(P<0.05), In HP negative gastric cancer group, the positive expression of COX-2was higher than in HP negative gastric ulcer group (intestinal metaplasia+dysplasia)(P<0.05). The positive expression was statistically higher in HP positive group than in HP negative group, and higher expression in HP positive gastric ulcer group (intestinal metaplasia+dysplasia) than in the HP negative gastric ulcer group(intestinal metaplasia+dysplasia)(all the P<0.05). Conclusion:①In gasrtic ulcer group (intestinal metaplasia, dysplasia) and gastric cancer group, COX-2was expressed in inflammatory cells, epithelial cells and cancer cells and a very small amount of normal mucosal epithelial cells. COX-2is usually not expressed in normal tissue, only when stimulated by various substances such as Inflammatory mediators, cytokines, cancer-promoting agent.②From normal gastric mucosa,gastic ulcer(intestinal metaplasia,dysplasia) to gastric cancer, the positive expression of COX-2is gradually increasing,he positive expression of COX-2was higher in dysplasia group than in intestinal metaplasia group the excessive expression of COX-2is responsible for gastric precancerous lesions and occurrence and development of gastric cancer. COX-2positive gastric ulcer (hyperplasia) is an important a premalignant lesion.③Gastric mucosal inflammation activity in HP positive patients is significantly higher than in HP negative patients. HP infectious gastric ulcer malignant transformation rate higher than without HP infection.④Over-expression of COX-2in HP positive gastric mucosa exacerbated inflammatory response and accelerated the process from normal gastric mucosa,gasrtic ulcer(intestinal metaplasia, dysplasia) to gastric cancer, HP infection may induce overexpression of COX-2that involving in the development of early stage gastric cancer.Gastric ulcer with COX-2high expression are more likely to the cancer.⑤HP infection and COX-2cause occurrence and development of gastric cancer.HP infectious gastric ulcer with COX-2the high expression, cancerous rate increased.