Clinical Observation Of Qixiantiaozhi Decoction With Lifestyle Interventions Improve Dyslipidemia In Postmenopausal Women

Objective:Observing the clinical effects of Qixiantiaozhi Decoction with lifestyle interventions in the improvement of dyslipidemia in early postmenopausal women of deficiency of the kidney and spleen yang,and the impacts of lipid levels and sex hormone levels,to explore the mechanism of the therapeutic of this treatment.Methods:Choosing 65 cases of early postmenopausal dyslipidemia patients which according to the inclusion criteria,randomly divided into two groups by visiting order,the experimental group was 33 cases and the control group was 32 cases.The experimental group adopted Qixiantiaozhi Decoction combined with the interventions of diet and exercise therapy of menopausal-day-clinic,the control group was only given oral traditional chinese medicines.Observing the changes of traditional chinese clinical symptoms,blood lipid levels and sex hormone leveis in 2 groups after three months of treatments,Withdrawal after 3 months follow-up record the changes of the TCM syndromes.Results:1.Overall clinical efficacy:comparing the total effective rate,the experimental group was 86.7%,which was better than that of the control group of 63.3%,the difference was statistically significant(P<0.05).2.TCM syndrome impovement:in Traditional Chinese medicine,the effective rate of the experimental group was 86.7%,the control group was 60%,P<0.01,indicting the experimental group was significantly better than the control group;in single symptom and TCM symptom scale,the two groups after treatment and follow-up were all ameliorated than before treatments,andt the experimental group was superior to the control group,P<0.05,there was statistical difference.3.Lipid levels changes:in terms of lipid improvement,The total effective rate of the experimental group was 86.7%,higher than that of the control group of 60%,P<0.01,which had statistically significant;after treatments,the lipid levels of two groups were significant improvement,for the reduction of the TC?LDL-C and the increased of the HDL-C,the experimental group was significantly better than that of the control group(P<0.01).4.Changes in hormone leves:no significant difference in hormone levels before treatment,P>0.05;The two groups of E2 were slightly elevated,but no statistically significant,T,SHBG improved,P<0.05;By contrast,the experimental group was significantly better than the control group in raising SHBG,and P = 0.01,which was statistically significant.5.During the study,five patients were dislodged for low compliance or loss to follow-up,including 3 in the experimental group and 2 in the control group.No adverse events occurred.Conclusion:Qixiantiaozhi Decoction can relieve the sympotom of early postmenopausal dyslipidemia of deficiency of the kidney and spleen yang,adjusting patients' blood lipid levels,improving their quality of life,combined with diet and exercises therapy interventions the effect is better.