Effects Of Exercise Combined Diet On The Indexes Of Nonalcoholic Fatty Liver (NAFL) In Rats

Objective:The project intends to choose different intensities of exercise combined with diet habits common intervention and to explore diet combined with exercise of different intensities of nonalcoholic fatty liver disease intervention effect, for the prevention and treatment of non alcoholic fatty liver provide theoretical and experimental data.Method:In this study, 5 week old SD healthy male rats(70 rats) were randomly divided into normal control group(LF), 60 rats were fed with high fat diet for 10 weeks, and the experimental model was established.After successful modeling, modeling the success of non alcohol fatty liver rats were divided to 4 groups,respectively, for the high fat turn normal diet control group(n = 13)(HF to LF), high fat diet control group(n = 13)(HF), the high fat turn normal diet of moderate intensity exercise group(n = 13)(HF lf medium exercise), high fat turn normal diet and high intensity exercise group 13(HF lf high exercise), and normal control group with 10 rats(LF), a total of five groups. 3 control group did not exercise, the exercise group was treadmill training, training 1 times a day, 5 days a week, rest for 2 days, a total of 6 weeks of training.Blood glucose was measured before training in all the experimental rats. At the end of the last training, 24 hours after the relevant indicators were measured..Result:(1) weight: after modeling, there was a significant difference between the body weight and the control group(P<0.01) in the group of non alcoholic fatty liver rats. Compared with the normal group, the weight of the exercise group was significantly decreased(P<0.05).(2) in weight and body fat index: perirenal fat, epididymal fat and brown fat body coefficient and LF group compared to rats in the HF group of perirenal fat body coefficient is significantly higher, the difference obviously(P < 0.05); with HF to LF group compared to the exercise group rats kidney week fat body coefficient decreased significantly, statistical difference significantly(P < 0.05).HLD between rats rats although very obvious rats rats compared to.(3) Serum biochemical indexes: and HF LF group and HF group TC, LDL, ALT and AST wereincreased but not significantly(P > 0.05), TG increased significantly(P < 0.01), Glu significantly increased(P < 0.01); HF lf medium group TC, Glu underground drop(P < 0.001), TG decreased significantly(P <0.05), LDL, ALT and AST decreased but not significantly(P > 0.05); HF lf high group TC and TG decreased(P > 0.05), LDL and AST was significantly decreased(P < 0.05), alanine aminotransferase(ALT)and Glu is obvious decreased(P < 0.01). Each group had no significant difference(P > 0.05).(4) liver tissue structure and lipid accumulation in liver cells: compared with the LF group, the lipid accumulation in the liver cells of HF group(HE staining) was significantly increased, and the liver lesions were severe. Compared with the to LF HF group, the lipid accumulation in the liver cells of the rats in the exercise group was significantly reduced, and the liver lesions were obviously improved.Conclusion:(1) Long term high fat diet will lead to obesity and metabolic disorders caused by the liver, liver steatosis, blood lipid and glucose metabolism caused by abnormal, abnormal liver function.(2) Non alcoholic fatty liver can be effectively controlled by diet and exercise intervention and recovery of different intensity.