Based On The Traditional Chinese Medicine Inheritance System, The Prescription Of Traditional Chinese Medicine For The Treatment Of Unruptured Follicular Luteinized Syndrome Prescriptions Was Discussed

Luteinized Follicle Sundrome(LUFS)means that the follicles are normally mature but because of various reasons,they do not rupture and the egg cells cannot be discharged smoothly.Granulosa cells are luteinized in-situ under the stimulation of luteinizing hormone(LH)to form the corpus luteum and secrete progesterone,resulting in hormone regulation by the body.It produces a series of similar ovulation changes,such as a more regular menstrual cycle,biphasic changes in basal body temperature,secretory phase changes during endometrial menstruation.It is a special type of anovulatory menstruation and is a common cause of infertility in women of childbearing age.With the improvement of medical ultrasound detection technology in recent years,and the current implementation of the policy of opening up the second child in the country and the growing demand for fertility,the LUFS has been mentioned more and more.Since Jewelewiez first reported the symptoms related to the disease in 1975 and named it LUFS,the related professional fields of Chinese and Western medicine have paid more attention to this disease.Due to different diagnostic methods and diagnostic criteria,the incidence of this disease is not identical.It has been reported in the literature that the incidence of this disease can reach 31.8%-42%in the ovulation cycle,and the recurrence rate is 63.6%.The incidence of natural cycles in women of normal reproductive age can also be as high as 5%-10%,and the incidence of infertility women is 25%-43%.Clinically,LUFS is commonly seen in Polycystic Ovarian Syndrome(PCOS),endometriosis,Hyperpro lactinemia(HPRL),and Pelvic Inflammatory Disease(PID),artificially promoted cycle,etc.Since the LUFS has no obvious clinical manifestations,and most patients have normal menstrual cycle,biphasic basal body temperature changes,cervical mucus changes(fissured dentate crystallization),so give the illusion of normal ovulation.At present the vaginal ultrasound monitoring of ovulation and female hormone levels are the preferred methods for diagnosing LUFS.With the development of assisted reproductive technology.Chinese medicine and Western medicine have made great progress in the prevention and treatment of this disease.However,at present,different traditional Chinese medicine or traditional Chinese and western medicine has its own strengths,and there is not much iroutation in the use of prescriptions.It's difficult for other follow-up clinicians to make decisions based on treatment experience.Therefore,this project uses Traditional Chinese Medicine Inheritance Support System to study the prescription patterns of traditional Chinese medicine treatment of LUFS prescriptions,and expects to provide a certain reference for the choice of drug treatment for clinical treatment.OBJECTIVE:By using the Traditional Chinese Medicine Inheritance Support System jointly developed by the Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences and the Institute of Automation,Chinese Academy of Sciences to conduct a comprehensive search of LUFS-related medical journals and select representative treatments,LUFS's Chinese herbal formulas are comprehensively and systematically analyzed in the hope of benefitting clinical treatment of this disease.RESEARCH METHOD:This topic adopts the method of data mining research and extracts the currently available databases("Chinese Journal Full-text Database","Chinese Sci-tech Journal Full-text Database" and "the Wanfang Data Resource System")in the treatment of LUFS in the literature journals.The prescriptions can be analyzed and summarized through the Traditional Chinese Medicine Inheritance Support System,and the frequency,drug compatibility combination,and drug relevance of the composition of LUFS prescriptions can be summarized and analyzed.The core composition and new prescription analysis of the drugs can be summarized based on the data results.RESEARCH RESULTS:1.The paper of LUFS treatment of traditional Chinese medicine:We read 159 articles of LUFS in Chinese medicine and filterd 86 articles in the literature.Among them,there are 1 article for the treatment of traditional Chinese patent medicine and 85 articles for the of traditional Chinese medicine.2.86 articles summed up 123 prescriptions,involving 147 Chinese herbal medicines,using 1457 times.The top 10 Chinese herbal medicines are:Angelica,Dodder,Rehearsal,Akasaka,White Pelican,Salvia,Epimedium,Safflower,Rhizoma Cyperi,Medlar.3.With the aid of the "Formula Analysis-Formula Rule" in the "Data Analysis System" module of the TCMISS,the combination of the top ten for the combination of drugs included in the prescription is:?Dodder,Angelica(56);?Rehearsal,Angelica(53);?Rehearsal,Dodder(48);?Angelica,White Pelican(45);?Akasaka,Angelica(44);?Safflower,Angelica(42);? Dodder,Epimedium(38);?Epimedium,Angelica(38);?Rehearsal,Dodder,Angelica(38);?Dodder,White Pelican(37),and access to a drug-related network diagram.4.The core drugs are:Angelica,Dodder,Rehearsal,Akasaka.White Pelican,Salvia,Epimedium,Safflower,Rhizoma Cyperi,Medlar,Kawashima,Hawthorn,Teasel,Peach kerne,Poria cocos,Yam.The core combinations are:?Rehearsal,White Pelican?Angelica(0.97),?Teasel?Dodder(0.93),?Kawashima?Angelica(0.92),?Rehearsal,Medlar?Dodder(0.89),?Safflower,Dodder?Angelica(0.88),?Safflower,Akasaka?Angelica(0.88),?White Pelican?Angelica(0.85),?Medlar?Dodder(0.85),?Hawthorn,Angelica?Rehearsal(0.84),?Dodder,White Pelican?Angelica(0.84).5.The new prescription analysis can be drawn:? Peach Kernel-Red Peony-Safflower-Cooked Land;?Codonopsis Pilosula Parasitic-Eucommia-Albazium;?Radix Rehmanniae-Dodder-Saffron-Wolfberry;?Fructus Auranti-Cangshu-Dannan Star Tuckahoe;? Parasitic-Peach Kernel-Safflower-Licorice;?Angelica-Glycyrrhiza-Peony-Saponins-Pangolin;?Coix Seed-Hawthorn Mustard;?Radix Angelicae Officinalis-Fructus Corni-Pimarin-Peach Kernel;?Angelica Sinensis-Fructus Trifoliate-Fructus Auranti-Pericarp;? Radix Paeoni-Peony-Peony Skin;11Herba Epimedium-Poria Peony Skin-Pericarp;12Radix Angelicae Sinensis-Radix Paeoniae Officinalis;13Corydalis Radix Rehmanniae-Angelica-Kawa Ko.CONCLUSION:1.Traditional Chinese medicine for unruptured follicular luteinization syndrome is:angelica sinensis,Cuscuta chinensis,Radix Rehmanniae,Radix Paeoniae Alba-Radix Paeoniae Alba,Radix Salviae Miltiorrhizae,Herba Epimedii,Carthamus safflower,Cortex Cyperus and Wolfberry.2.The combination of traditional Chinese medicine in the treatment of unruptured follicular luteinization syndrome is as follows:?Dodder seed,Angelica sinensis;?Ripe Rehmannia glutinosa and Angelica sinensis;?Cooked Rehmannia glutinosa and Cuscuta chinensis;?Angelica and Paeoniae Alba;? Red peony,angelica sinensis;?Safflower,angelica sinensis;?Dodder seed,Epimedium;?Epimedium,Angelica sinensis;?Ripe Rehmannia glutinosa,Cuscuta chinensis,Angelica sinensis;? Dodder,peony.3.Chinese medicine treatment of unruptured follicular luteinization syndrome may consider the choice of:On the basis of the blood supplement of the Si Wu Tang,and medicine such as Yam.Cornel.Dodder.Lycium Barbarum.Herba Epimedium,Supplemented by red peony,Ligusticum Chuan Xiong.Peach Kernel,Red Flower,Salvia Miltiorrhiza,and Xiang Fu to promote blood circulation,and according to the disease type and menstrual cycle choose Poria,Southern Star,Pinellia Ternata,Tangerine Phlegm,and Saponins and Pangolin Dredge collaterals and lead to medicine.